Metabolic engineering strategies for L-Homoserine production in Escherichia coli [PDF]
Microbial Cell FactoriesL-Homoserine, serves as a non-essential precursor for the essential amino acids derived from L-aspartate in both animals and humans. It finds widespread applications across the food, cosmetics, pharmaceutical, and animal feed industries.
Xin Jin +4 more
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Identification and Characterization of an O-Succinyl-L-Homoserine Sulfhydrylase From Thioalkalivibrio sulfidiphilus [PDF]
Frontiers in Chemistry, 2021 L-methionine is an important natural amino acid with broad application prospects. A novel gene encoding the enzyme with the ability to catalyze O-succinyl-L-homoserine (OSH) to L-methionine was screened and characterized.
Wen-Yuan Zhu +11 more
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Priming winter wheat seeds with the bacterial quorum sensing signal N-hexanoyl-L-homoserine lactone (C6-HSL) shows potential to improve plant growth and seed yield. [PDF]
PLoS ONE, 2019 Several model plants are known to respond to bacterial quorum sensing molecules with altered root growth and gene expression patterns and induced resistance to plant pathogens.
Olena V Moshynets +7 more
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Targeting Candida albicans O-acetyl-L-homoserine sulfhydrylase (Met15p) in antifungal treatment [PDF]
Scientific ReportsFungal infections are a serious threat to public health as they are becoming increasingly frequent. A major problem stems also from a rising fungal resistance to currently available antifungal therapies, therefore novel molecular targets are highly ...
Aleksandra Kuplińska +6 more
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Toxic effect and inability of L-homoserine to be a nitrogen source for growth of Escherichia coli resolved by a combination of in vivo evolution engineering and omics analyses [PDF]
Frontiers in Microbiology, 2022 L-homoserine is a pivotal intermediate in the carbon and nitrogen metabolism of E. coli. However, this non-canonical amino acid cannot be used as a nitrogen source for growth.
Ceren Alkim +12 more
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Identification and functional characterization of a potential l-Homoserine exporter in Corynebacterium glutamicum [PDF]
Engineering MicrobiologyExporter protein systems play a crucial role in the efficient production of valuable chemicals. However, the lack of active exporters significantly limits the application of industrial bio-based production, making the identification and utilization of ...
Xiaodi Liu +3 more
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Decoupled tricarboxylic acid cycle and glycolysis of Corynebacterium glutamicum combined with acetate supply promote high-yield biosynthesis of l-homoserine [PDF]
Synthetic and Systems Biotechnologyl-Homoserine is a valuable intermediate with broad applications in the food, pharmaceutical, and chemical industries. Although Corynebacterium glutamicum has been engineered for the efficient biosynthesis of l-homoserine, both production efficiency and ...
Daobin Wang +6 more
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Metabolic Engineering of Escherichia coli for the Production of l‑Homoserine [PDF]
Chem & Bio Engineeringl-Homoserine embodies significant functional properties as an amino acid of utmost importance, showcasing remarkable utility within the industrial realm.
Yijie Sun +3 more
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Crystal structure of N-(3-oxobutanoyl)-l-homoserine lactone [PDF]
Acta Crystallographica Section E: Crystallographic Communications, 2016 The structure and absolute configuration of the title compound, C8H11NO4, which is a known quorum-sensing modulator, have been determined. The molecule exhibits signs of an intramolecular attractive carbonyl–carbonyl n→π* interaction between the amide ...
R.W. Newberry, R.T. Raines
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Exploring the transcriptome of luxI− and ΔainS mutants and the impact of N-3-oxo-hexanoyl-L- and N-3-hydroxy-decanoyl-L-homoserine lactones on biofilm formation in Aliivibrio salmonicida [PDF]
PeerJ, 2019 Background Bacterial communication through quorum sensing (QS) systems has been reported to be important in coordinating several traits such as biofilm formation.
Miriam Khider +4 more
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