Results 241 to 250 of about 312,266 (316)

Cuproplasia and cuproptosis, two sides of the coin

Cancer Communications, EarlyView.
Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory ...
Kaizhong Lu, Chandra Sugiarto Wijaya, Qinghua Yao, Hongchuan Jin, Lifeng Feng   +4 more
wiley   +1 more source

Probing Lactate Dehydrogenase Activity in Tumors by Measuring Hydrogen/Deuterium Exchange in Hyperpolarized l-[1-¹³C,U-²H]Lactate

, 2012
Brett W. C. Kennedy, Mikko I. Kettunen, De‐En Hu, Kevin M. Brindle   +3 more
openalex   +1 more source

Native and Recombinant Yeast Producers of Lactic Acid: Characteristics and Perspectives. [PDF]

Int J Mol Sci
Tsaruk A, Filip K, Sibirny A, Ruchala J.
europepmc   +1 more source

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan, Jinling Song, Yuqing Ren, Yuyuan Zhang, Yuhao Ba, Peng Luo, Quan Cheng, Hui Xu, Siyuan Weng, Anning Zuo, Shutong Liu, Xinwei Han, Jinhai Deng, Zaoqu Liu   +13 more
wiley   +1 more source

Cardiovascular effects of lactate in healthy adults: D-lactate, the forgotten enantiomer-authors' reply. [PDF]

Crit Care
Berg-Hansen K, Pedersen MGB, Gopalasingam N, Rittig N, Søndergaard E, Møller N, Nielsen R.   +6 more
europepmc   +1 more source

An open‐label, single‐arm, multicenter, phase II trial of bireociclib as monotherapy for heavily pretreated HR‐positive, HER2‐negative advanced breast cancer patients: BRIGHT‐1 trial

Cancer Communications, EarlyView.
Abstract Background Bireociclib (XZP‐3287) is a novel selective cyclin‐dependent kinase 4 and 6 (CDK4/6) inhibitor, with a favorable safety profile demonstrated in preclinical and phase I studies. BRIGHT‐1 aimed to further explore the efficacy and safety of bireociclib monotherapy in patients with locally advanced, recurrent or metastatic, hormone ...
Jiayu Wang, Qingyuan Zhang, Tao Sun, Huiping Li, Ying Cheng, Zhongsheng Tong, Huihui Li, Wei Li, Jingfen Wang, Yuee Teng, Xinhong Wu, Jing Cheng, Zhendong Chen, Zhengqiu Zhu, Li Wang, Mingming Liu, Xianghui Duan, Lingmei Xu, Binghe Xu   +18 more
wiley   +1 more source

Protein lactylation in cancer: mechanisms and potential therapeutic implications. [PDF]

Exp Mol Med
Rho H, Hay N.
europepmc   +1 more source

Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation

Cancer Communications, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with immune evasion and energy metabolism reprogramming.
Jinhua Jiang, Feng Liu, Dan Cui, Caixia Xu, Jiachang Chi, Tinghua Yan, Fang Guo   +6 more
wiley   +1 more source

Construction and validation of a nomogram for identifying the patients at risk for rapid progression of advanced hormone-sensitive prostate cancer. [PDF]

BMC Cancer
Xu X, Fei W, Wu M, He Y, Yang B, Lv C.
europepmc   +1 more source

Clinical value of dysregulated miR-125b-5p in severe pneumonia children. [PDF]

BMC Immunol
Zhu M, Lu Z, Liao X, Liang Q, Xu C, Luo X, Li J.   +6 more
europepmc   +1 more source