Results 251 to 260 of about 312,266 (316)

The prognostic value of a laboratory cachexia score (LCAS) defined by LDH, CRP and albumin in patients with advanced lung cancer. [PDF]

BMC Cancer
Thompson JJ, MacLeod N, Will S, O'Rourke F, McGovern J, Roxburgh C, Edwards J, Dolan RD, McMillan DC.   +8 more
europepmc   +1 more source

Chemical Characterization of Alphitonia neocaledonica (Schltr.) Guillaumin Bark Extract and Its Anti‐Inflammatory Activities

Chemistry &Biodiversity, EarlyView.
Study of the anti‐inflammatory activities and chemical characterization of Alphitonia neocaledonica (Schltr.) Guillaumin bark extract. ABSTRACT Alphitonia neocaledonica (Schltr.) Guillaumin is a small forest tree endemic of New Caledonia traditionally used to treat rheumatic pain and dermatoses.
Karl Huet, Philippe Georgel, Mohammed Nour, Mohamed Haddad, Edouard Hnawia, Mariko Matsui   +5 more
wiley   +1 more source

A missense mutation in PDHB gene: identification of the patient with pyruvate dehydrogenase deficiency and demonstration of pathogenicity in vitro. [PDF]

Ital J Pediatr
Li Y, Cheng L, Li X, Liu J, Yi L, Bo T.
europepmc   +1 more source

Impact of Mutational Status on Intracellular Effects of Cell‐Permeable CaaX Peptides in Pancreatic Cancer Cells

ChemBioChem, EarlyView.
This work deals with intracellular effects of cell‐permeable CaaX‐peptides, designed to influence prenylated proteins like KRas. The results show that after CaaX‐1 treatment, not only KRas expression and signaling are specifically altered in mutated pancreatic cancer cells, but also plasma membrane localization of KRas is affected.
Merlin Klußmann, Martin Matijass, Ines Neundorf   +2 more
wiley   +1 more source

Ex vivo Coronary Angiography: Safety of Iopromide in Cold Preservation of Pig Hearts. [PDF]

Braz J Cardiovasc Surg
Zhulkov MO, Sirota DA, Zykov IS, Poveshchenko OV, Surovtseva MA, Kim IA, Protopopov AV, Sabetov AK, Agaeva KA, Makaev AG, Nadeev AP, Kliver VE, Kliver EE, Volkov AM, Karmadonova NA, Smirnov YM, Limanskiy AD, Tarkova AR, Chernyavskiy AM.   +18 more
europepmc   +1 more source

First Steps toward the Design of Peptides that Influence the Intracellular Palmitoylation Machinery

ChemBioChem, EarlyView.
Herein, DC peptides consisting of the cell‐penetrating peptide sC18* and a Asp–His–His–Cys (DHHC) motif derived from human ZDHHC palmitoyltransferase are highlighted. DC peptides demonstrate high cellular internalization into various cellular models, exert cytotoxic effects against cancerous cells, and alter the function and localization of known ...
Katharina Stillger, Eric Platz‐Baudin, Florian Friedland, Melina Ruppel, Coco‐Louisa Sticker, Anne Bodenhausen, Erik Noetzel, Ines Neundorf   +7 more
wiley   +1 more source

Moderate aerobic exercise improves haematological indices without altering cardio-metabolic enzyme activities in sedentary healthy young adults. [PDF]

BMC Sports Sci Med Rehabil
Okon IA, Beshel JA, Owu DU, Orie NN, Jim AE, Edet LI.   +5 more
europepmc   +1 more source

Machine Learning‐Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a

ChemMedChem, EarlyView.
Heart failure involves reduced SERCA2a activity, crucial for calcium regulation in heart cells. This study reports machine learning screening of 57,423 natural products, identifying several structurally related SERCA2a activators. Three compounds enhance calcium transport in cardiac cells, despite off‐target effects, offering promising hits for ...
Carlos Cruz‐Cortés, Eli Fernández‐de Gortari, Rodrigo Aguayo‐Ortiz, Jaroslava Šeflová, Adam Ard, Martin Clasby, Justus Anumonwo, L. Michel Espinoza‐Fonseca   +7 more
wiley   +1 more source

Development of an early prediction model for vomiting during hemodialysis using LASSO regression and Boruta feature selection. [PDF]

Sci Rep
Chen J, Shen C, Xue H, Yuan B, Zheng B, Shen L, Fang X.   +6 more
europepmc   +1 more source

The D-lactate enigma: exploring the inflammatory influence of D-lactate in cattle. [PDF]

Front Vet Sci
Burgos RA, Manosalva C, Alarcón P, Navarro M, Quiroga J, Morán G, Gallastegui J, Brauchi S, Carretta MD.   +8 more
europepmc   +1 more source