Results 241 to 250 of about 275,928 (338)

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Positive association between LDH to albumin ratio and arthritis: A cross-sectional NHANES study (1999-2010). [PDF]

Medicine (Baltimore)
Wu M, Liu C, Zheng M, Wei Z, Sun X.
europepmc   +1 more source

The ldhA Gene, Encoding Fermentative l -Lactate Dehydrogenase of Corynebacterium glutamicum , Is under the Control of Positive Feedback Regulation Mediated by LldR

, 2009
K. Toyoda, Haruhiko Teramoto, Masayuki Inui, Hideaki Yukawa   +3 more
openalex   +2 more sources

Nicotinamide Reverses the Warburg Effect in CHO Cell Culture

Biotechnology and Bioengineering, EarlyView.
Abstract The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey, Ayca Cankorur‐Cetinkaya, Luigi Grassi, Annie J. Harwood‐Stamper, Jonathan Welsh, Ryte Poskute, Kasia Kozakowska‐McDonnell, Cleo Kontoravdi   +7 more
wiley   +1 more source

Lactate dehydrogenase-to-albumin ratio for the severity of coronary artery disease in acute myocardial infarction: A retrospective study. [PDF]

J Int Med Res
Wu H, Wu Z, Xin Y, Jiang X, Guo C.
europepmc   +1 more source

Protein thermal stability in the undergraduate biochemistry laboratory: Exploring protein thermal stability with yeast alcohol dehydrogenase

Biochemistry and Molecular Biology Education, Volume 53, Issue 2, Page 209-217, March/April 2025.
Abstract We created a novel laboratory experience where undergraduate students explore the techniques used to study protein misfolding, unfolding, and aggregation. Despite the importance of protein misfolding and aggregation diseases, protein unfolding is not typically explored in undergraduate biochemistry laboratory classes.
Alison Bates, Kathryn M. Williams, Ann E. Hagerman   +2 more
wiley   +1 more source

Associations of lactate dehydrogenase with risk of respiratory disease mortality among cancer survivors. [PDF]

Medicine (Baltimore)
Tang L, Chen J, Tan H.
europepmc   +1 more source

Use of L-Lactate Dehydrogenase Immobilized on Carboxylated Multiwalled Carbon Nanotubes/Polyaniline/Pencil Graphite Electrode as a Lactate Biosensor

Ali Toprak, Nazlı Ece Varan, Gökmen Sığırcık, Deniz Yıldırım, Tunç Tüken, S. Seyhan Tükel, Dilek Alagöz   +6 more
openalex   +2 more sources

Theoretical site-directed mutagenesis. The Asp168Ala mutant of L-Lactate Dehydrogenase

, 2008
Vicent Moliner, Silvia Ferrer Castillo, Estanislao Silla, Iñaki Tuñón, Ian H. Williams   +4 more
openalex   +2 more sources

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source