Results 81 to 90 of about 13,561,049 (255)
Advanced Science, EarlyView.Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He +9 more
wiley +1 more source
, 2012 L-lactate dehydrogenase (LDH) converts pyruvate to lactate when oxygen is absent or in short supply, and the enzyme plays a crucial role in cancer metabolism. The functions of many mammalian proteins are modulated by posttranslational modifications (PTMs)
Zhou WD +7 more
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Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Serum Lactate Dehydrogenase: A Diagnostic Test for Acute Leukemia Subtypes
Cyprus Journal of Medical SciencesBACKGROUND/AIMS: Acute leukemia can be categorized into two primary subtypes, acute lympho-blastic leukemia (ALL) and acute myeloid leukemia (AML), each of which necessitates distinct thera-peutic strategies.
Amin A. Alamin +2 more
doaj +1 more source
Lactate dehydrogenase activity in abdominal fluid from horses with colic [PDF]
, 2016 The purpose of this study was to determine whether lactate dehydrogenase (LDH) activity in abdominal fluid could be used as a prognostic indicator in horses with colic.
Mills, J. +3 more
core
Advanced Science, EarlyView.In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang +6 more
wiley +1 more source
Advanced Science, EarlyView.A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu +8 more
wiley +1 more source
Progressive bilateral leg edema due to intravascular large B-cell lymphoma
Journal of Hospital General MedicineAn 81-year-old woman presented with subacute progressive bilateral leg edema without fever or weight loss. Laboratory tests showed elevated C-reactive protein (4.89 mg/dL) and lactate dehydrogenase (1314 U/L) levels.
Risa Hirata +3 more
doaj +1 more source
, 1976 The fructose‐1,6‐bisphosphate‐activated l‐lactate dehydrogenase (EC 1.1.1.27) from Lactobacillus casei ATCC 393 has been purified to homogenity by including affinity chromatography (cibacronblue‐Sephadex‐G‐200) and preparative polyacrylamide gel ...
Gordon G.L., Doelle H.W.
core +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source