Results 101 to 110 of about 229,589 (299)

In vitro antihistamine-releasing activity of a peptide derived from wasp venom of Vespa orientalis

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To investigate the antihistamine-releasing effect of a peptide isolated from wasp venom of Vespa orientalis. Methods: This peptide was separated from crude venom by chromatography methods and mass spectrometry.
Jafar Jalaei, Mehdi Fazeli, Hamid Rajaian, Somayeh Layeghi Ghalehsoukhteh, Alireza Dehghani, Dominic Winter   +5 more
doaj   +1 more source

Recombinant production, purification, and biochemical characterization of a novel L-lactate dehydrogenase from Bacillus cereus NRC1 and inhibition study of mangiferin. [PDF]

Front Bioeng Biotechnol, 2023
Esa SS, El-Sayed AF, El-Khonezy MI, Zhang S.   +3 more
europepmc   +1 more source

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

Progressive bilateral leg edema due to intravascular large B-cell lymphoma

Journal of Hospital General Medicine
An 81-year-old woman presented with subacute progressive bilateral leg edema without fever or weight loss. Laboratory tests showed elevated C-reactive protein (4.89 mg/dL) and lactate dehydrogenase (1314 U/L) levels.
Risa Hirata, Kiyoshi Shikino, So Motomura, Masaki Tago   +3 more
doaj   +1 more source

Effects of freezing rate on structural changes in L-lactate dehydrogenase during the freezing process. [PDF]

Sci Rep, 2021
Park H, Park JY, Park KM, Chang PS.
europepmc   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Interaction of lactate dehydrogenase isoenzymes with ligands [PDF]

, 1988
Isoenzymes of bovine lactate dehydrogenase (H4, H3M, and H2M2) were prepared by affinity chromatography on a 5'-AMP-Sepharose 4B column. The interaction of isoenzymes with two ligands, coenzyme NADH and the competitive inhibitor Cibacron Blue F3GA was ...
Jana Kučerová, Jana Barthová, Sylva Leblová   +2 more
core   +1 more source

Characterization of a Novel Thermostable Dye-Linked l-Lactate Dehydrogenase Complex and Its Application in Electrochemical Detection. [PDF]

Int J Mol Sci, 2021
Satomura T, Uno K, Kurosawa N, Sakuraba H, Ohshima T, Suye SI.   +5 more
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Enantioselective Biosynthesis of L-Phenyllactic Acid From Phenylpyruvic Acid In Vitro by L-Lactate Dehydrogenase Coupling With Glucose Dehydrogenase. [PDF]

Front Bioeng Biotechnol, 2022
Zhang D, Zhang T, Lei Y, Lin W, Chen X, Wu M.   +5 more
europepmc   +1 more source