Human d‐lactate dehydrogenase deficiency by LDHD mutation in a patient with neurological manifestations and mitochondrial complex IV deficiency [PDF]
JIMD Reports, 2021 Background d‐lactate, one of the isomers of lactate, exists in a low concentration in healthy individuals and it can be oxidized to pyruvate catalyzed by d‐lactate dehydrogenase.
Anna Ka‐Yee Kwong +5 more
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Identification of human D lactate dehydrogenase deficiency [PDF]
Nature Communications, 2019 D-lactic acidosis typically occurs in the context of short bowel syndrome; excess D-lactate is produced by intestinal bacteria. Here, the authors identify two point mutations in the human lactate dehydrogenase D (LDHD) gene that cause enzymatic loss of ...
Glen R. Monroe +27 more
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Characterization of a membrane-bound PQQ-dependent d-lactate dehydrogenase in Gluconobacter japonicus [PDF]
Applied Microbiology and BiotechnologyMembrane-bound pyrroloquinoline quinone (PQQ)–dependent quinoproteins are key components of the periplasmic oxidative metabolism of acetic acid bacteria, yet several predicted enzymes remain experimentally uncharacterized.
Naoya Kataoka +5 more
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Human D‐Lactate Dehydrogenase Deficiency: A Case Report in a Young Boy [PDF]
JIMD ReportsD‐lactate is an isomeric form of lactate, which is almost undetectable in the circulation in individuals with normal lactate metabolism. Patients diagnosed with the disease human D‐lactate dehydrogenase deficiency present with elevated plasma D‐lactate ...
T. B. Sloth +5 more
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The D-Lactate Dehydrogenase from Sporolactobacillus inulinus Also Possessing Reversible Deamination Activity. [PDF]
PLoS ONE, 2015 Hydroxyacid dehydrogenases are responsible for the conversion of 2-keto acids to 2-hydroxyacids and have a wide range of biotechnological applications.
Lingfeng Zhu +4 more
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Shotgun metagenomic mining reveals a new FAD-dependent D-lactate dehydrogenase in an isopod gut microbiome [PDF]
Applied and Environmental MicrobiologyShotgun metagenomic sequencing has emerged as a powerful tool for exploring microbial diversity and uncovering genes encoding novel biocatalysts from complex environments.
Catarina Coelho +8 more
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Biophysical and Biochemical Characterization of TP0037, a
mBio, 2020 A longstanding conundrum in Treponema pallidum biology concerns how the spirochete generates sufficient energy to fulfill its complex pathogenesis processes during human syphilitic infection.
Ranjit K. Deka +3 more
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Silencing of D-Lactate Dehydrogenase Impedes Glyoxalase System and Leads to Methylglyoxal Accumulation and Growth Inhibition in Rice [PDF]
Frontiers in Plant Science, 2017 D-Lactate is oxidized by two classes of D-lactate dehydrogenase (D-LDH), namely, NAD-dependent and NAD-independent D-LDHs. Little is known about the characteristics and biological functions of D-LDHs in rice. In this study, a functional NAD-independent D-
Baoguang An +8 more
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Nature Communications, 2023 Mammalian lactate dehydrogenase D (LDHD) catalyzes the oxidation of D-lactate to pyruvate. LDHD mutations identified in patients with D-lactic acidosis lead to deficient LDHD activity. Here, we perform a systematic biochemical study of mouse LDHD (mLDHD)
Shan Jin +3 more
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Characterization of the L-lactate dehydrogenase from Aggregatibacter actinomycetemcomitans. [PDF]
PLoS ONE, 2009 Aggregatibacter actinomycetemcomitans is a Gram-negative opportunistic pathogen and the proposed causative agent of localized aggressive periodontitis. A.
Stacie A Brown, Marvin Whiteley
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