Results 121 to 130 of about 275,928 (338)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Evaluation of Metanephrine and Lactate Dehydrogenase in Pediatric Wilms Tumor and Neuroblastom

مجلة كلية الطب
Background: Wilms' tumor and Neuroblastoma are common pediatric malignancies, with biochemical markers like plasma metanephrines and serum lactate dehydrogenase (LDH) being studied for diagnostic and prognostic values.
Nihad A. Jwda, Manal K. Rasheed , Hasanein H.Ghali   +2 more
doaj   +1 more source

Recombinant production, purification, and biochemical characterization of a novel L-lactate dehydrogenase from Bacillus cereus NRC1 and inhibition study of mangiferin. [PDF]

Front Bioeng Biotechnol, 2023
Esa SS, El-Sayed AF, El-Khonezy MI, Zhang S.   +3 more
europepmc   +1 more source

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

Effects of freezing rate on structural changes in L-lactate dehydrogenase during the freezing process. [PDF]

Sci Rep, 2021
Park H, Park JY, Park KM, Chang PS.
europepmc   +1 more source

Structure‐Function Relationship in the Allosteric l‐Lactate Dehydrogenases from Lactobacillus casei and Lactobacillus curvatus [PDF]

, 1982
Ulrich Mayr, Reinhard Hensel, Matthias P. Deparade, Hans Pauly, Gerhard Pfleiderer, Wolfgang E. Trommer   +5 more
openalex   +1 more source

A role for von Hippel-Lindau protein in pancreatic beta-cell function. [PDF]

, 2009
ObjectiveThe Vhlh gene codes for the von Hippel-Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing.
Cano, David A, Hebrok, Matthias, Puri, Sapna   +2 more
core  

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Characterization of a Novel Thermostable Dye-Linked l-Lactate Dehydrogenase Complex and Its Application in Electrochemical Detection. [PDF]

Int J Mol Sci, 2021
Satomura T, Uno K, Kurosawa N, Sakuraba H, Ohshima T, Suye SI.   +5 more
europepmc   +1 more source

?????? ????????? ???????????? ????????? ????????? ?????????????????? ??????????????? ?????????????????? ?????? [PDF]

, 2019
Department of Chemical EngineeringUtilizing carbon dioxide to valuable chemicals is attractive technology for reducing CO2 emission. Among the chemicals converted from CO2, formic acid is one of the most valuable chemicals. Efficient conversion of CO2 to
Kim, Hee Gon
core