Results 121 to 130 of about 13,561,049 (255)

Lactate dehydrogenase isoenzymes linked to an immunoglobulin

, 1980
An unusual lactate dehydrogenase isoenzyme pattern was found in a patient admitted to the intensive care unit of Mercy Hospital, Mount Vernon, Ohio, and probable causes were investigated.
Miller, Joyce Catherine
core  

Interaction of lactate dehydrogenase isoenzymes with ligands

, 1988
Isoenzymes of bovine lactate dehydrogenase (H4, H3M, and H2M2) were prepared by affinity chromatography on a 5'-AMP-Sepharose 4B column. The interaction of isoenzymes with two ligands, coenzyme NADH and the competitive inhibitor Cibacron Blue F3GA was ...
Jana Kučerová, Jana Barthová, Sylva Leblová   +2 more
core   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Malic enzyme 1 senses L-lactate to determine tumor heterogeneity

Signal Transduction and Targeted Therapy
L-lactate is generally elevated in tumors and acts as a signaling molecule that promotes tumor progression. Here, we reveal that malic enzyme 1 (ME1) functions as a previously unrecognized sensor of L-lactate through direct binding at arginine 155 (R155),
Si-Yi Cao, Kewen Hu, Shijing Huang, Xiao-Lin Guan, Jian Wang, Yuan Shen, Hui Ming, Aihong Gu, Chao Wang, Xiao Shen, Qing Wu, Zhengjun Chen, Miao Yin, Wenyu Wen, Qun-Ying Lei   +14 more
doaj   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Production of Lactate by Metabolically Engineered Scheffersomyces stipitis

Journal of Fungi
Lactate is a valuable compound used in food, chemical, and pharmaceutical industries. High-value, optically pure L- or D-lactate can be synthesized microbially via specific dehydrogenases.
Angela Matanović, Nenad Marđetko, Ana Slišković, Blanka Didak, Karla Hanousek Čiča, Bojan Žunar, Anamarija Štafa, Božidar Šantek, Marina Svetec Miklenić, Ivan-Krešimir Svetec   +9 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Bio-Mimicking Pyruvate to Inhibit Lactate Dehydrogenase [PDF]

, 2012
Lactate dehydrogenase is an enzyme that catalyzes the reaction of converting pyruvic acid into lactic acid. This reaction took place at pH 7.0. Molecules, such as acetamide and oxamic acid, which are believed to mimic pyruvate in terms of hydrogen ...
Brockington, Davita Nicole, NC DOCKS at The University of North Carolina at Pembroke   +1 more
core  

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Careful CO Addition Enhances Autotrophic d‐Lactate Formation With Engineered Acetobacterium woodii

Engineering in Life Sciences
The acetogen A. woodii efficiently converts CO2 and H2 to acetate. Metabolic engineering enabled the autotrophic production of non‐native products, for example, d‐lactate from CO2 by overexpression of d‐lactate dehydrogenase from Leuconostoc ...
Anna Stock, Inka Sotzeck, Kira Baur, Frank Bengelsdorf, Dirk Weuster‐Botz   +4 more
doaj   +1 more source