Results 141 to 150 of about 13,561,049 (255)

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Organic Nanozyme‐Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression

Advanced Science, EarlyView.
A temperature‐sensitive hydrogel loaded with cyanine nanozymes and Escherichia coli is locally injected into postoperative tumor resection beds. Upon light irradiation, synergistic PTT and PDT work with cascaded reactive oxygen species to deplete extracellular GSH, eliminate residual tumor cells, and induce robust antitumor immune responses for ...
Cong Jiang, Zifan Yang, Rong Guo, Meng Suo, Guowei Wang, Dong Chen, Lilin Su, Fuhuan Wang, Shipeng Ning, Kelong Fan, Xuan Wang   +10 more
wiley   +1 more source

Lactate dehydrogenase has no control on lactate production but has a strong negative control on formate production in Lactococcus lactis

, 2001
A series of mutant strains of Lactococcus lactis were constructed with lactate dehydrogenase (LDH) activities ranging from below 1% to 133% of the wild-type activity level.
Pedersen, M.B., Andersen, H.W., Hammer, Karin, Jensen, Peter Ruhdal   +3 more
core  

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

l-Lactate Dehydrogenase B Chain Associated with Milk Protein Content in Dairy Cows. [PDF]

Animals (Basel), 2019
Wang T, Jeon SW, Jung US, Kim MJ, Lee HG.   +4 more
europepmc   +1 more source

Lactate Dehydrogenase-to-Albumin Ratio as a Predictor of In-Hospital Mortality in Predicted Severe Acute Pancreatitis: Evidence from an 18-Year Cohort Study [PDF]

Yaoyu Zou,* Maobin Kuang,* Shixuan Xiong,* Xin Xu, Xueyang Li, Ling Ding, Cong He, Nianshuang Li, Huajing Ke, Xin Huang, Yupeng Lei, Huifang Xiong, Wenhua He, Liang Xia, Nonghua Lu, Jianhua Wan, Yin Zhu Department of ...
Ke H, He C, Zhu Y, Xiong S, Ding L, Li N, Zou Y, Li X, Lu N, Xia L, He W, Huang X, Lei Y, Kuang M, Wan J, Xu X, Xiong H   +16 more
core  

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

The assembly of tetrameric human L-lactate dehydrogenase is regulated by ionic strength, β-NADH binding, cyclic peptides, and long-chain dicarboxylates. [PDF]

Protein Sci
Stefan A, Gentilucci L, Barbiroli AG, Rossi V, Liao H, Di Stefano G, He T, Hochkoeppler A.   +7 more
europepmc   +1 more source

Interface Residues That Drive Allosteric Transitions Also Control the Assembly of l-Lactate Dehydrogenase. [PDF]

J Phys Chem B, 2018
Chen J, Thirumalai D.
europepmc   +1 more source