Results 131 to 140 of about 229,589 (299)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Production of Lactate by Metabolically Engineered Scheffersomyces stipitis

Journal of Fungi
Lactate is a valuable compound used in food, chemical, and pharmaceutical industries. High-value, optically pure L- or D-lactate can be synthesized microbially via specific dehydrogenases.
Angela Matanović, Nenad Marđetko, Ana Slišković, Blanka Didak, Karla Hanousek Čiča, Bojan Žunar, Anamarija Štafa, Božidar Šantek, Marina Svetec Miklenić, Ivan-Krešimir Svetec   +9 more
doaj   +1 more source

D- and L-lactate dehydrogenases of Pseudomonas aeruginosa [PDF]

Biochemical Journal, 1972
openaire   +2 more sources

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Lactate Dehydrogenase-A-Forming LDH5 Promotes Breast Cancer Progression [PDF]

Tianxing Fang,1– 4 Liyu Hu,5 Tianshun Chen,4 Fei Li,6 Liu Yang,4 Bin Liang,7 Wenjun Wang,8 Fancai Zeng4 1Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Nuclear Medicine ...
Yang L, Fang T, Li F, Wang W, Hu L, Zeng F, Chen T, Liang B   +7 more
core   +1 more source

Cerebrospinal fluid lactate and lactate dehydrogenase activity in the rapid diagnosis of bacterial meningitis [PDF]

, 1986
CITATION: Donald, P. R. & Malan, C. 1986. Cerebrospinal fluid lactate and lactate dehydrogenase activity in the rapid diagnosis of bacterial meningitis. South African Medical Journal, 69:39-42.The original publication is available at http://www.samj.org ...
Malan, C., Donald, P. R.
core  

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Bio-Mimicking Pyruvate to Inhibit Lactate Dehydrogenase [PDF]

, 2012
Lactate dehydrogenase is an enzyme that catalyzes the reaction of converting pyruvic acid into lactic acid. This reaction took place at pH 7.0. Molecules, such as acetamide and oxamic acid, which are believed to mimic pyruvate in terms of hydrogen ...
Brockington, Davita Nicole, NC DOCKS at The University of North Carolina at Pembroke   +1 more
core  

Careful CO Addition Enhances Autotrophic d‐Lactate Formation With Engineered Acetobacterium woodii

Engineering in Life Sciences
The acetogen A. woodii efficiently converts CO2 and H2 to acetate. Metabolic engineering enabled the autotrophic production of non‐native products, for example, d‐lactate from CO2 by overexpression of d‐lactate dehydrogenase from Leuconostoc ...
Anna Stock, Inka Sotzeck, Kira Baur, Frank Bengelsdorf, Dirk Weuster‐Botz   +4 more
doaj   +1 more source