Results 91 to 100 of about 229,589 (299)

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

Lactate dehydrogenase activity in abdominal fluid from horses with colic [PDF]

, 2016
The purpose of this study was to determine whether lactate dehydrogenase (LDH) activity in abdominal fluid could be used as a prognostic indicator in horses with colic.
Mills, J., Myles, R., Gaál, T., Smuts, C.   +3 more
core  

Serum Levels of Lactate Dehydrogenase and Alkaline Phosphatase Enzymes in Colorectal Cancer [PDF]

, 2019
Colorectal cancer (CRC) remains one of the main public health problems throughout the world. It has recently been observed that both of lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) enzymes play critical role in cancer expansion.
Mohammed Imran Hamzah, Abeer Khalid Yaseen, Batool Hassan Al-Ghurabi   +2 more
core   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Serum Lactate Dehydrogenase: A Diagnostic Test for Acute Leukemia Subtypes

Cyprus Journal of Medical Sciences
BACKGROUND/AIMS: Acute leukemia can be categorized into two primary subtypes, acute lympho-blastic leukemia (ALL) and acute myeloid leukemia (AML), each of which necessitates distinct thera-peutic strategies.
Amin A. Alamin, Amna F. Bashir, Hammad Tufail Chaudhary   +2 more
doaj   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Lactate dehydrogenase isoenzymes linked to an immunoglobulin [PDF]

, 1980
An unusual lactate dehydrogenase isoenzyme pattern was found in a patient admitted to the intensive care unit of Mercy Hospital, Mount Vernon, Ohio, and probable causes were investigated.
Miller, Joyce Catherine
core  

Developmental Changes in Ruminant Lactate Dehydrogenase [PDF]

, 1964
Developmental progressions of ruminant lactate dehydrogenase have been described in terms of electrophoretic patterns, substrate-activity ratios, and the percentage of subunit types present.
Masters, C. J., Hinks, Mary
core   +1 more source

An Energy Autonomous Microneedle Array‐Based Sensing System for Continuous Biomarker Monitoring

Advanced Science, EarlyView.
This work presents an innovative self‐powered wearable biosensor system for real‐time monitoring of multiple biomarkers in interstitial fluid. The device integrates stainless steel‐based minimally invasive microneedles with ion‐selective membranes, enabling simultaneous Na+, K+, Ca2+, pH, and glucose detection.
Arnab Pal, Kai‐Po Fan, Sheng‐Chun Hung, Jaba Roy Chowdhury, Jun‐Hsun Chung, Meenakshi Ray, Hsiang‐Yun Hsu, Fu‐Cheng Kao, Kuei‐Lin Liu, Zong‐Hong Lin   +9 more
wiley   +1 more source