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L-malic acid production by an albino strain of Monascus araneosus

World Journal of Microbiology & Biotechnology, 1993
An albino mutant was isolated after treating Monascus araneosus AHU9087 with N-methyl-N'-nitro-N-nitrosoguanidine. All other physiological and biochemical characteristics were retained. The mutant did not produce any pigment but produced L-malic acid at 28 g/l, compared with 20 g/l by the parent strain, in media containing 10% (w/v) glucose after ...
S, Lumyong, F, Tomita
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A Concise Synthesis of (R)-GABOB from L-Malic Acid

Synthetic Communications, 1995
Abstract A concise synthesis of (R)-4-amino-3-hydroxybutanoic acid, starting from L-malic acid, is reported. The approach is based on the conversion of the oxazolidin-2-one 9 into a full protected form of (®)-GABOB by an Arndt-Eistert reaction.
Domenico Misiti   +2 more
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Fully integrated L-malic acid production process

2011
Bioconversion of fumaric acid to L-malic acid was performed using biocatalyst fumarase from whole permeabilized baker’s yeast cells Saccharomyces cerevisiae in a continuous stirred tank reactor, with biomass recirculation and in situ product separation. The process of in situ product separation consisted of five processing steps: biotransformation, the
Pandurić, Nikola   +2 more
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Kinetic determination of l(−)malic acid in wines using sequential injection analysis

Analytica Chimica Acta, 2003
In the present work a sequential injection system for the enzymatic determination of L(-)malic acid in wines is described. The determination was based on the detection of NADH, formed by oxidation of L-malate to oxaloacetate, catalysed by L-malate dehydrogenase.
Segundo, Marcela A.   +1 more
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Recovery of fumaric acid by membrane crystallization in the production of l-malic acid

Separation and Purification Technology, 2003
A study on redesigning traditional crystallizers by using microporous hydrophobic membranes and, in particular, the realization of a separation unit aiming to recover the unreacted fumaric acid leaving a biocatalytic membrane reactor for the production of L-malic acid is presented.
Curcio E, Di Profio G, Drioli E
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L-malic acid production by entrappedSaccharomyces cerevisiae into polyacrylamide gel beads

Applied Biochemistry and Biotechnology, 1994
The yeast Saccharomyces cerevisiae was entrapped within polyacrylamide gel beads by employing a procedure that uses sodium dodecylsulfate as a detergent to improve the spherical configuration of the beads. The resulting preparation showed a rate of fumarate bio-conversion to L-malic acid about 60 times higher than that found for the free cells.
E A, Oliveira   +3 more
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Continuous synthesis of l-malic acid using whole-cell microreactor

Process Biochemistry, 2012
Abstract Although whole-cell biocatalysis, as well as microreactor technology, are gaining importance in modern biotechnology, there are just a few literature reports on whole-cell biocatalysis in microreactors. In the present work, a continuously operated microreactor with permeabilized Saccharomyces cerevisiae cells was made out of commercially ...
Gorazd Stojkovič   +1 more
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Fully integrated production of L-malic acid

2010
L-malic acid is a dicarboxylic acid and an intermediate of cell metabolism. It belongs to a group of „bulk“ chemicals with estimated consumption of 40, 000 tons per year. It is widely distributed in nature where it occurs in very low concentrations. It can be prepared by extraction from natural fruit juices or by bioconversion of fumaric acid with an ...
Kovačević, Tatjana, Zelić, Bruno
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Biotransformation of fumaric to L-malic acid

2005
Jabučna kiselina spada u grupu visoko tonažnih kemikalija s potrošnjom od otprilike 40000 t godišnje. Jedna je od najčešćih organskih tvari u prirodi i vrlo bitna komponenta u staničnom metabolizmu. Uglavnom se upotrebljava u farmaceutskoj industriji, prehrambenoj i kozmetičkoj industriji kao konzervans (zamjena za limunsku kiselinu). Vrlo je efektivna
Vrsalović Presečki, Ana   +2 more
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Different Complexation of Nd3+ and Sm3+ with L-Malic Acid

Russian Journal of Coordination Chemistry, 2004
Complexation of Nd3+ and Sm3+ ions with L-malic acid (H3Mal) in aqueous solutions (I = 0.1 mol/l KCl) was studied by pH-metric titration at the molar concentration ratios of H3Mal : lanthanide equal to 1 : 2, 1 : 1, 2 : 1 in the pH range 2.8–9.5.
I. V. Sukhno   +3 more
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