Results 91 to 100 of about 1,103,850 (332)

Theory of pseudoclassical confinement and transition to L mode

Physics of Fluids B: Plasma Physics, 1993
A theory of the self-sustained turbulence is developed for resistive plasma in toroidal devices. Pseudoclassical confinement is obtained in the low-temperature limit. As temperature increases, the current diffusivity prevails upon resistivity, and the turbulence nature changes so as to recover the L-mode transport.
K. Itoh, S.-I. Itoh, M. Yagi, A. Fukuyama, M. Azumi   +4 more
openaire   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

High confinement regimes on SPARC: operational conditions for access and avoidance

Nuclear Fusion
This work examines H-mode and I-mode access on the SPARC tokamak, combining new simulations of core L-mode power balance with the best empirical scalings available for L–H and L–I thresholds.
J.W. Hughes, P. Rodriguez-Fernandez, A.E. Hubbard, D.J. Battaglia, M.A. Miller, A. Cavallaro, N.T. Howard, T.M. Wilks, A.J. Creely   +8 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

On Principal Admissible Representations and Conformal Field Theory

, 1999
The principal admissible representations of affine Kac-Moody algebras are studied, with a view to their use in conformal field theory. We discuss the generation of the set of principal admissible highest weights, concentrating mainly on $A_r^{(1)}$ at ...
Aln, Awata, Bauer, Bernard, Bowcock, Dong, Dunbar, Dunbar, Feigen, Frenkel, Fuchs, Furlan, Furlan, Furlan, Gawedzki, Gepner, Kac, Kac, Kac, Koh, Lerche, Lu, M.A. Walton, Malikov, Mathieu, Mathieu, Moore, P. Mathieu, Petersen, Petersen, Rasmussen   +30 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Conformational Analyses of Physiological Binary and Ternary Copper(II) Complexes with l‐Asparagine and l‐Histidine; Study of Tridentate Binding of Copper(II) in Aqueous Solution

ChemistryOpen, 2019
This study explores the structural properties and energy landscapes of the physiologically important bis(l‐asparaginato)copper(II) [Cu(l‐Asn)2] and (l‐histidinato)(l‐asparaginato)copper(II) [Cu(l‐His)(l‐Asn)]. The conformational analyses in the gas phase
Prof. Michael Ramek, Dr. Marijana Marković, Ilina Mutapčić, Jelena Pejić, Prof. Anne‐Marie Kelterer, Dr. Jasmina Sabolović   +5 more
doaj   +1 more source