Results 81 to 90 of about 1,124,073 (259)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Radial variation of heat transport in L-mode JET discharges

Nuclear Fusion, 2019
In this paper, we analyze heat transport in the JET tokamak using data from its high resolution ECE diagnostic and analyses based on the transfer entropy (TE). The analysis reveals that heat transport is not smooth and continuous, but is characterized by 'trapping regions' separated by 'minor transport barriers'. Heat may 'jump over' these barriers and
van Milligen B Ph, Carreras A, de la Luna E, Solano E R, Abduallev S, Abhangi M, Abreu P, Afzal M, Aggarwal K M, Ahlgren T, Ahn J H, AhoMantila L, Aiba N, Airila M, Albanese R, Aldred V, Alegre D, Alessi E, Aleynikov P, Alfier A, Alkseev A, Allinson M, Alper B, Alves E, Ambrosino G, Ambrosino R, Amicucci L, Amosov V, Sunden E Andersson, Angelone M, Anghel M, Angioni C, Appel L, Appelbee C, Arena P, Ariola M, Arnichand H, Arshad S, Ash A, Ashikawa N, Aslanyan V, Asunta O, Auriemma F, Austin Y, Avotina L, Axton M D, Ayres C, Bacharis M, Baciero A, Baiao D, Bailey S, Baker A, Balboa I, Balden M, Balshaw N, Bament R, Banks J W, Baranov Y F, Barnard M A, Barnes D, Barnes M, Barnsley R, Wiechec A Baron, Orte L Barrera, Baruzzo M, Basiuk V, Bassan M, Bastow R, Batista A, Batistoni P, Baughan R, Bauvir B, Baylor L, Bazylev B, Beal J, Beaumont P S, Beckers M, Beckett B, Becoulet A, Bekris N, Beldishevski M, Bell K, Belli F, Bellinger M, Belonohy E, Ben Ayed N, Benterman N A, Bergsaker H, Bernardo J, Bernert M, Berry M, Bertalot L, Besliu C, Beurskens M, Bieg B, Bielecki J, Biewer T, Bigi M, Bilkova P, Binda F, Bisoffi A, Bizarro J P S, Bjorkas C, Blackburn J, Blackman K, Blackman T R, Blanchard P, Blatchford P, Bobkov V, Boboc A, Bodnar G, Bogar O, Bolshakova I, Bolzonella T, Bonanomi N, Bonelli F, Boom J, Booth J, Borba D, Borodin D, Borodkina I, Botrugno A, Bottereau C, Boulting P, Bourdelle C, Bowden M, Bower C, Bowman C, Boyce T, Boyd C, Boyer H J, Bradshaw J M A, Braic V, Bravanec R, Breizman B, Bremond S, Brennan P D, Breton S, Brett A, Brezinsek S, Bright M D J, Brix M, Broeckx W, Brombin M, Broslawski A, Brown D P D, Brown M, Bruno E, Bucalossi J, Buch J, Buchanan J, Buckley M A, Budny R, Bufferand H, Bulman M, Bulmer N, Bunting P, Buratti P, Burckhart A, Buscarino A, Busse A, Butler N K, Bykov I, Byrne J, Cahyna P, Calabro G, Calvo I, Camenen Y, Camp P, Campling D C, Cane J, Cannas B, Capel A J, Card P J, Cardinali A, Carman P, Carr M, Carralero D, Carraro L, Carvalho B B, Carvalho I, Carvalho P, Casson F J, Castaldo C, Catarino N, Caumont J, Causa F, Cavazzana R, CaveAyland K, Cavinato M, Cecconello M, Ceccuzzi S, Cecil E, Cenedese A, Cesario R, Challis C D, Chandler M, Chandra D, Chang C S, Chankin A, Coda S, de Pablos J L, Enachescu M, Fanni A, Fresa R, Gervasini G, Huijsmans G T A, Innocente P, Jardin A, Kos B, Koskela T, Laguardia L, Loarte A, Lukin A, Makwana R, Marchetto C, Matejcik S, Murari A, Muraro A, Paccagnella R, Pasqualotto R, Plyusnin V, Pomaro N, Puiatti M E, Romanelli F, Ruiz M, Sauter O, Soare S, Sozzi C, Subba F, Tardocchi M, Terranova D, Testa D, Tokitani M, Uccello A, Vianello N, Vicente J, Wischmeier M   +237 more
openaire   +5 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Waste to Hydrogen: Transforming Food Waste Into Biohythane (Bio‐H2 + Bio‐CH4) in a Two‐Stage Reactor With the Aid of a Metal‐Ion Catalyst

Energy Science & Engineering
This study aimed to enhance biohythane (biohydrogen [bio‐H2] + biomethane [bio‐CH4]) production from food waste (FW) via dark fermentation (DF) using a two‐stage anaerobic bioreactor system with specially developed seed cultures and metal‐ion catalysts ...
K. V. Sreedharan, Debabrata Barik, Ayyar Dinesh, D. Shanmugapriya, M. Santhamoorthy, N. Ashok   +5 more
doaj   +1 more source

Dimensionality correct power law scaling expressions for L-mode confinement

Nuclear Fusion, 1991
Confinement scalings of divertor and radiofrequency heated discharges are shown to differ significantly from the standard neutral beam heated limiter scaling. The random coefficient two stage regression algorithm is applied to a neutral beam heated limiter subset of the ITER L mode database as well as a combined dataset.
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Gyrokinetic study of multiple electrostatic and electromagnetic electron-temperature-gradient modes and relevant transport in tokamak finite βe plasmas

Nuclear Fusion
We present a comprehensive study of the multiple electrostatic and electromagnetic electron temperature gradient (ETG) modes with a significant upgrading of the gyrokinetic code HD7.
X.R. Zhang, X. Jian, J.Q. Dong, Z.X. Wang, Y.P. Zou, S. Xu, J. Li, Y.Y. Li, S. Zheng, Q.B. Luan, M.K. Han, R.R. Ma, Y. Shen, W. Chen   +13 more
doaj   +1 more source

Updated Sensitivities of the Five STIS L-mode Gratings

Re-derivation of the sensitivities of all of the Space Telescope Imaging Spectrograph (STIS) observing modes were required after major updates were introduced to the model atmospheres of the three primary standard stars. The new predicted continuum fluxes were up to 2-3% different from the models used to originally calibrate STIS.
Jones, Amy M., Hernandez, Svea, Carlberg, Joleen K., Welty, Daniel   +3 more
openaire   +2 more sources