Results 91 to 100 of about 729,292 (310)

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

O bloqueio da síntese do óxido nítrico promove aumento da hipertrofia e da fibrose cardíaca em ratos submetidos a treinamento aeróbio Nitric oxide synthesis blockade increases hypertrophy and cardiac fibrosis in rats submitted to aerobic training

Arquivos Brasileiros de Cardiologia, 2007
OBJETIVO: O presente estudo avaliou as adaptações teciduais cardíacas em ratos submetidos a treinamento aeróbio, após o bloqueio da síntese de óxido nítrico (NO). MÉTODOS: Os animais (n = 48) foram divididos em quatro grupos: sedentários (grupo CONTROLE),
Hugo Celso Dutra de Souza, Daniel Martins Dias Penteado, Marli Cardoso Martin-Pinge, Octávio Barbosa Neto, Vicente de Paula Antunes Teixeira, João Henrique Dutra Blanco, Valdo José Dias da Silva   +6 more
doaj   +1 more source

Эндотелиопротективные эффекты тетрагидробиоптерина и L-аргинина [PDF]

, 2012
Рассматривается эндотелиопротективные эффекты тетрагидробиоптерина, L-аргинина и их комбинации на ADMA-подобной, L-NAME- индуцированной и гипергомоцистеин-индуцированной моделях эндотелиальной ...
Арустамова, А. А., Гудырев, О. С., Корокин, М. В., Корокина, Л. В., Саввин, В. А.   +4 more
core  

Efecto hipotensor del extracto de ajo (Allium sativum) macerado por 18 semanas en un modelo experimental in vivo

Revista Peruana de Medicina Experimental y Salud Pública
Objetivos. Determinar si el extracto de ajo (Allium sativum) macerado por 18 semanas tiene igual o mejor efecto hipotensor que el captopril en ratas. Materiales y métodos. Se realizó un estudio experimental in vivo con ratas machos Holtzman, clasificados
David Chaupis-Meza, Juan Rojas, Manuel Gasco, Gustavo F Gonzales   +3 more
doaj   +2 more sources

L-NAME causes antinociception by stimulation of the arginine-NO-cGMP pathway

Mediators of Inflammation, 2000
NG-nitro-L-arginine methyl ester (L-NAME) has been used extensively as a paradigmatic inhibitor of NO synthase and has been shown to cause antinociception in several experimental models.
I. D. G. Duarte, S. H. Ferreira
doaj   +1 more source

Rosuvastatin prevents proteinuria and renal inflammation in nitric oxide-deficient rats

Clinics, 2011
OBJECTIVE: The aim of the present study was to assess the effects of rosuvastatin on renal injury and inflammation in a model of nitric oxide deficiency.
Jose Marcos Girardi, Rogerio Estevan Farias, Ana Paula Ferreira, Nadia Rezende Barbosa Raposo   +3 more
doaj   +1 more source

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties [PDF]

, 2011
Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to ...
Gibson, Colin, Kunuthur, S. P., Milliken, P. H., Suckling, C. J., Wadsworth, R. M.   +4 more
core   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Морфологические изменения сердечно-сосудистой системы при моделировании L-NAME индуцированной эндотелиальной дисфункции в течение 28 дней [PDF]

, 2012
Изучение морфологических изменений сердечно-сосудистой системы в результате развития эндотелиальной дисфункции на 28-дневной модели L-NAME-индуцированного дефицита оксида ...
Белоус, А. С.
core   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source