Results 261 to 270 of about 714,437 (290)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

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Preglomerular Sudanophilia in L-NAME Hypertensive Rats

Hypertension, 1996
Abstract To characterize alterations of renal vessels occurring during systemic hypertension elicited in rats by 5, 10, and 25 days of treatment by the nitric oxide synthase inhibitor N G -nitro- l -arginine methyl ester (L-NAME) (20 mg/kg daily), preglomerular ...
N, Bouriquet, M, Dupont, A, Herizi, A, Mimran, D, Casellas   +4 more
openaire   +2 more sources

Vasoactive systems in L-NAME hypertension

Journal of Hypertension, 2004
The contribution of the renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) to blood pressure (BP) maintenance was evaluated in rats with N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension. Furthermore, we studied the extent of nitric oxide (NO) synthesis inhibition and the participation of remaining NO in the ...
Olga, Pechánová, Zdenka, Dobesová, Jakub, Cejka, Jaroslav, Kunes, Josef, Zicha   +4 more
openaire   +2 more sources

l -NAME as a Synthetic Antioxidant in Liver Injuries

2018
Oxidative stress is attributable to a mismatch between the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as to the body’s antioxidant capacity to readily detoxify the reactive intermediates or mend the ensuing damage. RNS, such as nitric oxide (NO), are synthetized by nitric oxide synthases (NOS).
Ayhancı, Adnan, Appak, Sıla, Cengiz, Mustafa   +2 more
openaire   +2 more sources

L-NAME, a nitric oxide synthase inhibitor, modulates cholinergic antinociception

Methods and Findings in Experimental and Clinical Pharmacology, 1999
Systemic administration of sumatriptan and buspirone (20 mg/kg: 5-HT1A agonists) produced antinociception against acetic acid-induced writhing. The antinociceptive effect was potentiated by cholinomimetic physostigmine (0.05 mg/kg i.p.) and blocked by the muscarinic antagonist atropine (5 mg/kg i.p.).
N K, Jain, S K, Kulkarni
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l-NAME inhibits pentylenetetrazole and strychnine-induced seizures in mice

Brain Research, 1997
Nitric oxide (NO) formation has been shown in many neuronal tissues subserves a variety of functions. N-Methyl-D-aspartate (NMDA) receptor stimulation which releases nitric oxide and raises cGMP levels, mediates epileptiform activity induced by various agents. Disinhibition of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and/or activation
I, Kaputlu, T, Uzbay
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l-NAME precipitates catatonia during ethanol withdrawal in rats

Behavioural Brain Research, 2001
The effect of N(G)-nitro-L-arginine methyl ester (L-NAME), a non-specific inhibitor of nitric oxide (NO) synthase, on catatonia in ethanol dependent rats was investigated. Ethanol was given to rats by a modified liquid diet. An isocaloric liquid diet without ethanol was also given to control rats. L-NAME (50, 100 and 200 mg/kg) and saline were injected
openaire   +2 more sources

Effect of post-trial L-NAME administration on cocaine sensitization

International Journal of Neuroscience, 2013
This study determined if Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) administered after the cocaine-conditioning trial attenuated the development of sensitization to cocaine's locomotor-stimulating effect and secondly, determined if L-NAME blocked conditioned-locomotor activity (LMA) elicited by a saline-challenge injection.
Cindy M, Pudiak, Michael A, Bozarth
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L-NAME antagonizes vasopressin V2-induced vasodilatation in dogs

American Journal of Physiology-Heart and Circulatory Physiology, 1994
Experiments were performed in conscious chronically instrumented dogs to study the mechanism of hemodynamic effects mediated by selective vasopressin V2 agonists. In one group of dogs (n = 5) instrumented for the measurement of arterial pressure and cardiac output (electromagnetic flowmeter), the infusion of NG-nitro-L-arginine methyl ester (L-NAME ...
openaire   +2 more sources

Blood pressure variability in established L-NAME hypertension in rats

Journal of Hypertension, 1999
Blood pressure variability was evaluated in conscious Wistar control rats and rats with established L-NAME hypertension (20 mg/kg per 24 h, 4 weeks).Final systolic arterial pressure was 185+/-5 and 132+/-4 mm Hg in the Nomega-nitro-L-arginine methyl ester (L-NAME)-treated and control rats, respectively.
J, Blanc, P, Ponchon, D, Laude, J L, Elghozi, B, Jover   +4 more
openaire   +2 more sources