Reprogramming Immunogenicity of Iron Oxide Nanoparticles through Sulfated Glycan Presentation
Small, EarlyView.This study presents a comparative analysis of heparin (HP)‐ and dextran sulfate (DS)‐coated superparamagnetic iron oxide nanoparticles (SPIONs) as a tunable immunomodulatory platform where surface chemistry dictates therapeutic function. DS‐SPIONs are preferentially internalized by myeloid cells, reprogramming them into a pro‐healing M2 phenotype ...
Negin Pournoori +8 more
wiley +1 more source
Evaluation of cell adhesion molecules (LFA-1 and L-selectin) in ankylosing spondylitis patients after treatment with β-D-mannuronic acid (M2000). [PDF]
Indian J Med Res, 2023 Fattahi MJ +9 more
europepmc +1 more source
Small, EarlyView.Particular nanoparticles (PNPs), engineered with defined enrichment of leukocyte adhesion membrane proteins, demonstrate superior targeting of inflamed sites in a microfluidic inflamed vessel model under flow conditions. This selective membrane protein enrichment enhances targeting efficiency while improving nanoparticle production reproducibility and ...
Sivan Arber Raviv +4 more
wiley +1 more source
Increased L-Selectin on Monocytes Is Linked to the Autoantibody Profile in Systemic Sclerosis. [PDF]
Int J Mol Sci, 2022 Brezovec N +6 more
europepmc +1 more source
Targeted disruption of E-,P and L-selectin ligand biosynthesis is associated with a decrease in susceptibility to indomethacin-induced intestinal damage [PDF]
, 1998 PL Beck +4 more
openalex +1 more source
Single Cell Analysis Reveals Dynamic Changes of Distinct Cell Populations in Human Nickel Allergy
Allergy, EarlyView.We investigated cell types mediating the early and late inflammatory responses in human Ni2+‐allergy by scRNA‐Seq. Early responsiveness was mainly mediated by TLR4+TAGLN− endothelial cells indirectly activating TLR4−KRT16+ keratinocytes, and CCR7+DCN+ DCs. Late responsiveness was crucially driven by infiltration of KLF2+ central memory T cells and TLR4+
Marc Schmidt +7 more
wiley +1 more source
Brain Pathology, EarlyView.This post‐mortem study revealed an increased density of vessel‐associated microglia (VAM) in the temporal lobe in systemic infection and Alzheimer's disease. VAM density was related to brain cytokine levels and markers of cerebrovascular dysfunction and BBB leakage indicating that activated VAM contributes to neurovascular injury in Alzheimer's disease.
Oliver Milner +5 more
wiley +1 more source
TGFβ enhances platelet–breast‐cancer‐cell interaction and promotes platelet aggregation
The FEBS Journal, EarlyView.TGFβ stimulation promotes EMT in MCF7 cells, increasing their ability to bind, activate, and aggregate PLT. This effect involves the upregulation of adhesion molecules Integrin‐αv and Galectin‐3. Inhibiting Integrin‐αv or Galectin‐3, through Cilengitide and GB1103, reduces PLT adhesion to MCF7 and PLT aggregation, suggesting a mechanism linking TGFβ ...
Margherita Genitoni +7 more
wiley +1 more source
Signaling Functions of L-selectin [PDF]
Journal of Biological Chemistry, 1995 Thomas K. Waddell +4 more
openaire +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source