Results 1 to 10 of about 180,512 (263)

N-/T-Type vs. L-Type Calcium Channel Blocker in Treating Chronic Kidney Disease: A Systematic Review and Meta-Analysis. [PDF]

Pharmaceuticals (Basel), 2023
Renin-angiotensin system (RAS) inhibitors and calcium channel blockers (CCB) are often used together in chronic kidney disease (CKD). The PubMed, EMBASE, and Cochrane Library databases were searched to identify randomized controlled trials (RCTs) in ...
Zhao M, Zhang Z, Pan Z, Ma S, Chang M, Fan J, Xue S, Wang Y, Qu H, Zhang Y.   +9 more
europepmc   +2 more sources

Forskolin Regulates L-Type Calcium Channel through Interaction between Actinin 4 and β3 Subunit in Osteoblasts [PDF]

PLoS ONE, 2015
Voltage-dependent L-type calcium channels that permit cellular calcium influx are essential in calcium-mediated modulation of cellular signaling. Although the regulation of voltage-dependent L-type calcium channels is linked to many factors including ...
Xuemei Zhang, Fangping Li, Lin Guo, Hongya Hei, Lulu Tian, Wen Peng, Hui Cai   +6 more
openalex   +3 more sources

Tetrodotoxin-resistant mechanosensitivity and L-type calcium channel-mediated spontaneous calcium activity in enteric neurons. [PDF]

Exp Physiol
Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition in the enteric nervous system, using the GCaMP6f reporter in neural crest cell ...
Amedzrovi Agbesi RJ, El Merhie A, Spencer NJ, Hibberd T, Chevalier NR.   +4 more
europepmc   +2 more sources

Anticancer Effects of Antihypertensive L-Type Calcium Channel Blockers on Chemoresistant Lung Cancer Cells via Autophagy and Apoptosis. [PDF]

Cancer Manag Res, 2020
Bing-Sang Wong,1 Ling-Yen Chiu,2 Dom-Gene Tu,2,3 Gwo-Tarng Sheu,4– 6,* Ting-Tat Chan7,* 1Division of Neurosurgery, Antai Medical Care Corporation Antai Tian-Sheng Memorial Hospital, Pingtung County, Taiwan; 2Department of Nuclear Medicine ...
Wong BS, Chiu LY, Tu DG, Sheu GT, Chan TT.   +4 more
europepmc   +2 more sources

Sleep deprivation of rats increases postsurgical expression and activity of L-type calcium channel in the dorsal root ganglion and slows recovery from postsurgical pain. [PDF]

Acta Neuropathol Commun, 2019
Perioperative sleep disturbance is a risk factor for persistent pain after surgery. Clinical studies have shown that patients with insufficient sleep before and after surgery experience more intense and long-lasting postoperative pain.
Li Q, Zhu ZY, Lu J, Chao YC, Zhou XX, Huang Y, Chen XM, Su DS, Yu WF, Gu XY.   +9 more
europepmc   +2 more sources

Inhibition of Contractility of Isolated Caprine Detrusor by the Calcium Channel Blocker Cilnidipine and Reversal by Calcium Channel Openers

Current Therapeutic Research, 2023
: Background: Cilnidipine is a fourth-generation calcium channel blocker that is clinically used to treat hypertension. It is a dihydropyridine that blocks L- and N-type calcium channels.
Steffi A. Maria, MD, Aniket Kumar, PhD, Premila M. Wilfred, MD, Margaret Shanthi, MD, Jacob Peedicayil, MD   +4 more
doaj   +1 more source

Hydrogen sulfide inhibits L-type calcium currents depending upon the protein sulfhydryl state in rat cardiomyocytes. [PDF]

PLoS ONE, 2012
Hydrogen sulfide (H(2)S) is a novel gasotransmitter that inhibits L-type calcium currents (I (Ca, L)). However, the underlying molecular mechanisms are unclear. In particular, the targeting site in the L-type calcium channel where H(2)S functions remains
Rongyuan Zhang, Yan Sun, Haojan Tsai, Chaoshu Tang, Hongfang Jin, Junbao Du   +5 more
doaj   +1 more source

Effect of L/N-type Calcium Channel Blocker (Cilnidipine) on Oxidative Stress in Nitric Oxide-Deficient Hypertensive Rats [PDF]

BLDE University Journal of Health Sciences, 2020
Background: The sympathetic nervous system plays a major role in the renal function through the vasoactive system and the Renin-Angiotensin-Aldosterone System. Even though interest in the renal protective effects of sympathetic blocker has been increased,
Gouher Banu Shaikh, Surekha Hippargi, Dewan S A. Majid, M S Biradar, Kusal K Das   +4 more
doaj   +2 more sources

Differential calcium signaling mediated by voltage-gated calcium channels in rat retinal ganglion cells and their unmyelinated axons. [PDF]

PLoS ONE, 2014
Aberrant calcium regulation has been implicated as a causative factor in the degeneration of retinal ganglion cells (RGCs) in numerous injury models of optic neuropathy.
Allison Sargoy, Xiaoping Sun, Steven Barnes, Nicholas C Brecha   +3 more
doaj   +1 more source

Effect of Efonidipine on TGF-β1–Induced Cardiac Fibrosis Through Smad2-Dependent Pathway in Rat Cardiac Fibroblasts

Journal of Pharmacological Sciences, 2011
.: Transforming growth factor beta-1 (TGF-β1) plays a critical role in progression of cardiac fibrosis, which may involve intracellular calcium change. We examined effects of efonidipine, a dual T-type and L-type calcium channel blocker (CCB), on TGF-β1 ...
Bai Lei, Hirofumi Hitomi, Tatsuhiko Mori, Yukiko Nagai, Kazushi Deguchi, Hirohito Mori, Tsutomu Masaki, Daisuke Nakano, Hiroyuki Kobori, Yasushi Kitaura, Akira Nishiyama   +10 more
doaj   +1 more source