Results 121 to 130 of about 515,300 (403)
BIN1 localizes the L-type calcium channel to cardiac T-tubules.
PLoS Biology, 2010 The BAR domain protein superfamily is involved in membrane invagination and endocytosis, but its role in organizing membrane proteins has not been explored.
Ting-Ting Hong +8 more
doaj +1 more source
Increased Expression of the Cardiac L-type Calcium Channel in Estrogen Receptor–deficient Mice
The Journal of General Physiology, 1997 Steroid hormones control the expression of many cellular regulators, and a role for estrogen in cardiovascular function and disease has been well documented.
Barry D. Johnson +5 more
semanticscholar +1 more source
Drug treatment of hypertension: focus on vascular health [PDF]
, 2016 Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C. +2 more
core +1 more source
FEBS Open Bio, EarlyView.IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
wiley +1 more source
Journal of Biological Chemistry, 2003 l-Type calcium channels are multiprotein complexes composed of pore-forming (CaV1.2) and modulatory auxiliary α2δ- and β-subunits. We demonstrate expression of two different isoforms for the β2-subunit (β2a, β2b) and the β3-subunit (β3a, β3trunc) in ...
R. Hullin +6 more
semanticscholar +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Electrophysiological Mechanisms and Therapeutic Potential of Calcium Channels in Atrial Fibrillation
Reviews in Cardiovascular MedicineAtrial fibrillation (AF) is a prevalent and complex arrhythmia for which the pathogenesis involves various electrophysiological factors, notably the regulation of calcium channels.
Zuyuan Huang +3 more
doaj +1 more source
Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium
eLife, 2015 D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood.
Stephanie C Gantz +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
Cellular Calcium Regulation in Hypertension [PDF]
, 2017 In vascular muscle cells, two distinct types of functionally important calcium (Ca2++) channels, called transient (T) and sustained (L), are differentiated by dihydropyridine calcium antagonists (CaA).
Erne, P., Hermsmeyer, K.
core