Results 11 to 20 of about 180,512 (263)

The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression

Translational Neuroscience, 2022
The CACNA1C protein is a L-type calcium channel, which influence affective disorders.
Dam Henrik, Buch Jens O. D., Nielsen Annelaura B., Weikop Pia, Jørgensen Martin B.   +4 more
doaj   +1 more source

The Role of the L-Type Ca2+ Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy

JACC: Basic to Translational Science, 2016
Heterozygous mice (αMHC403/+) expressing the human disease-causing mutation Arg403Gln exhibit cardinal features of hypertrophic cardiomyopathy (HCM) including hypertrophy, myocyte disarray, and increased myocardial fibrosis.
Helena M. Viola, PhD, Victoria P.A. Johnstone, PhD, Henrietta Cserne Szappanos, PhD, Tara R. Richman, PhD, Tatiana Tsoutsman, PhD, Aleksandra Filipovska, PhD, Christopher Semsarian, MD, PhD, Jonathan G. Seidman, PhD, Christine E. Seidman, MD, PhD, Livia C. Hool, PhD   +9 more
doaj   +1 more source

L-type voltage-gated calcium channel agonists mitigate hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher syndrome type 1

Disease Models & Mechanisms, 2020
The mariner (myo7aa−/−) mutant is a zebrafish model for Usher syndrome type 1 (USH1). To further characterize hair cell synaptic elements in myo7aa−/− mutants, we focused on the ribbon synapse and evaluated ultrastructure, number and distribution of ...
Alaa Koleilat, Joseph A. Dugdale, Trace A. Christenson, Jeffrey L. Bellah, Aaron M. Lambert, Mark A. Masino, Stephen C. Ekker, Lisa A. Schimmenti   +7 more
doaj   +1 more source

Leukotriene B4 Inhibits L-Type Calcium Channels via p38 Signaling Pathway in Vascular Smooth Muscle Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Arachidonic acid (AA) and its metabolites are important endogenous lipid messengers. In this study, we test the effect of Leukotriene B4 (LTB4), a 5-lipoxygenase metabolite of AA, on L-type calcium channels in A7r5 rat aortic vascular ...
Xiaoyu Liu, Tingting Yang, Langxi Miao, Yan-Ai Mei, Changlong Hu   +4 more
doaj   +1 more source

Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II

Behavioral and Brain Functions, 2008
We study the voltage dependent calcium channels and nitric oxide involvement in angiotensin II-induced pressor effect. The antipressor action of L-Type calcium channel antagonist, nifedipine, has been studied when it was injected into the third ventricle
Guarda Ismael FMS, Saad Wilson A, Camargo Luiz AA, Santos Talmir AFB   +3 more
doaj   +1 more source

Differential Involvement of L-Type Calcium Channels in Epileptogenesis of Rat Hippocampal Slices during Ontogenesis

Neurobiology of Disease, 2000
Organic calcium channel antagonists block epileptiform activity in adult tissue, suggesting an essential role of L-type channels in epileptogenesis in the mature CNS.
R. Köhling, H. Straub, E.-J. Speckmann
doaj   +1 more source

Neuroprotective effects of blockers for T-type calcium channels

Molecular Neurodegeneration, 2009
Cognitive and functional decline with age is correlated with deregulation of intracellular calcium, which can lead to neuronal death in the brain.
Lei Debin, Baird Michelle A, Lin-Ye Avary, Wildburger Norelle C, Bao Jianxin   +4 more
doaj   +1 more source

Vascular Response of Tetrabromobisphenol a in Rat Aorta: Calcium Channels Inhibition and Potassium Channels Activation

Toxics, 2022
Tetrabromobisphenol A (TBBPA) is a flame retardant widely used to reduce flammability. It is an endocrine disruptor, and due to constant human exposure, some concerns have been raised regarding its impact on human health.
Joana Feiteiro, Sandra M. Rocha, Melissa Mariana, Cláudio J. Maia, Elisa Cairrao   +4 more
doaj   +1 more source

Apoptotic Cell Death and Impairment of L-Type Voltage-Sensitive Calcium Channel Activity in Rat Cerebellar Granule Cells Treated with the Prion Protein Fragment 106–126

Neurobiology of Disease, 2000
Prion diseases are neurodegenerative pathologies characterized by the accumulation, in the brain, of altered forms of the prion protein (PrP), named PrPSc.
Stefano Thellung, Tullio Florio, Valentina Villa, Alessandro Corsaro, Sara Arena, Carolina Amico, Mauro Robello, Mario Salmona, Gianluigi Forloni, Orso Bugiani, Fabrizio Tagliavini, Gennaro Schettini   +11 more
doaj   +1 more source

Ionic Mechanisms of Disopyramide Prolonging Action Potential Duration in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1

Frontiers in Pharmacology, 2020
Short QT syndrome (SQTS) is associated with tachyarrhythmias and sudden cardiac death. So far, only quinidine has been demonstrated to be effective in patients with SQTS type 1(SQTS1).
Huan Lan, Qiang Xu, Qiang Xu, Ibrahim El-Battrawy, Ibrahim El-Battrawy, Rujia Zhong, Xin Li, Siegfried Lang, Siegfried Lang, Lukas Cyganek, Lukas Cyganek, Martin Borggrefe, Martin Borggrefe, Xiaobo Zhou, Xiaobo Zhou, Xiaobo Zhou, Ibrahim Akin, Ibrahim Akin   +17 more
doaj   +1 more source