Results 21 to 30 of about 515,300 (403)

L-type voltage-gated calcium channel agonists mitigate hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher syndrome type 1

Disease Models & Mechanisms, 2020
The mariner (myo7aa−/−) mutant is a zebrafish model for Usher syndrome type 1 (USH1). To further characterize hair cell synaptic elements in myo7aa−/− mutants, we focused on the ribbon synapse and evaluated ultrastructure, number and distribution of ...
Alaa Koleilat, Joseph A. Dugdale, Trace A. Christenson, Jeffrey L. Bellah, Aaron M. Lambert, Mark A. Masino, Stephen C. Ekker, Lisa A. Schimmenti   +7 more
doaj   +1 more source

Calcium channels controlling acetylcholine release from preganglionic nerve terminals in rat autonomic ganglia [PDF]

, 1999
Little is known about the nature of the calcium channels controlling neurotransmitter release from preganglionic parasympathetic nerve fibres. In the present study, the effects of selective calcium channel antagonists and amiloride were investigated on ...
A.B Smith, Boot, Bowersox, Brock, Brock, D.J Adams, De Luca, Dunlap, Gonzalez-Burgos, Hong, Ireland, L Motin, Lavidis, Lin, Lundy, McDonough, Meir, N.A Lavidis, Randall, Randall, Rogers, Seabrook, Smith, Smith, Smith, Smith, Snider, Tabatabai, Tang, Todorovic, Warren, Waterman, Wright, Wu   +33 more
core   +1 more source

Leukotriene B4 Inhibits L-Type Calcium Channels via p38 Signaling Pathway in Vascular Smooth Muscle Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Arachidonic acid (AA) and its metabolites are important endogenous lipid messengers. In this study, we test the effect of Leukotriene B4 (LTB4), a 5-lipoxygenase metabolite of AA, on L-type calcium channels in A7r5 rat aortic vascular ...
Xiaoyu Liu, Tingting Yang, Langxi Miao, Yan-Ai Mei, Changlong Hu   +4 more
doaj   +1 more source

Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia

Channels, 2018
The voltage-gated L-type calcium channel (LTCC) is essential for multiple cellular processes. In the heart, calcium influx through LTCC plays an important role in cardiac electrical excitation.
Qing Zhang, Junjie Chen, Yao Qin, Juejin Wang, Lei Zhou   +4 more
semanticscholar   +1 more source

Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]

, 2012
Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Bennett, J., Hills, C. E., Liu, K.-K., Siamantouras, E., Squires, P. E., Younis, M. Y.G.   +5 more
core   +2 more sources

The roles of the subunits in the function of the calcium channel [PDF]

, 1991
Dihydropyridine-sensitive voltage-dependent L-type calcium channels are critical to excitation-secretion and excitation-contraction coupling. The channel molecule is a complex of the main, pore-forming subunit alpha 1 and four additional subunits: alpha ...
Biel, Martin, Dascal, Nathan, Flockerzi, V., Hofmann, Franz, Lotan, I., Singer, D.   +5 more
core   +1 more source

L-Type Calcium Channels [PDF]

Circulation Research, 2002
Voltage-gated calcium channels are essential for coupling membrane depolarization to the influx of calcium in all excitable cells. The calcium that flows into excitable cells through voltage-gated calcium channels serves a dual function, generating both electrical and chemical signals. The intracellular events controlled by calcium are diverse and many.
openaire   +1 more source

Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure [PDF]

, 2016
Pharmacological blockade of the N-and L-type calcium channel lessens renal injury in kidney disease patients. The significance of specific blockade of α1 subunit of N-type calcium channel, Cav2.2, in diabetic nephropathy, however, remains to be clarified.
Fujikura, Junji, Imamaki, Hirotaka, Ishii, Akira, Kasahara, Masato, Kuwabara, Takashige, Kuwahara, Koichiro, Mori, Kiyoshi, Mori, Yasuo, Mukoyama, Masashi, Naito, Masaki, Nakao, Kazuwa, Numata, Tomohiro, Ohno, Shoko, Saleem, Moin, Yanagita, Motoko, Yokoi, Hideki   +15 more
core   +4 more sources

Autophagy exacerbates electrical remodeling in atrial fibrillation by ubiquitin-dependent degradation of L-type calcium channel

Cell Death and Disease, 2018
Autophagy, a bidirectional degradative process extensively occurring in eukaryotes, has been revealed as a potential therapeutic target for several cardiovascular diseases. However, its role in atrial fibrillation (AF) remains largely unknown. This study
Yue Yuan, Jing Zhao, Y. Gong, Ding-yu Wang, Xiaoyu Wang, Fengxiang Yun, Zhaorui Liu, Song Zhang, Wenpeng Li, Xinbo Zhao, Li Sun, L. Sheng, Zhenwei Pan, Yue Li   +13 more
semanticscholar   +1 more source

Decreased myocardial injury and improved contractility after administration of a peptide derived against the alpha-interacting domain of the L-type calcium channel. [PDF]

, 2014
BackgroundMyocardial infarction remains the leading cause of morbidity and mortality associated with coronary artery disease. The L-type calcium channel (IC a-L) is critical to excitation and contraction.
Hool, Livia C, Jordan, Maria C, Roos, Kenneth P, Viola, Helena M   +3 more
core   +1 more source