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L-Type Calcium Channels Modulation by Estradiol
Molecular Neurobiology, 2016Voltage-gated calcium channels are key regulators of brain function, and their dysfunction has been associated with multiple conditions and neurodegenerative diseases because they couple membrane depolarization to the influx of calcium-and other processes such as gene expression-in excitable cells.
Nelson E, Vega-Vela +6 more
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Osteoblastic cells have L-type calcium channels
Bone and Mineral, 1989Whole cell patch clamp studies on osteoblast-like rat osteosarcoma cells (ROS 17/2.8) show the existence of L-type calcium channels in the cell membrane. Measurements were carried out at both 21 and 37 degrees C. With isotonic CsCl in the pipette and a bathing medium containing either 110 or 10 mM Ba2+, a strong depolarizing pulse was required to ...
C, Grygorczyk, R, Grygorczyk, J, Ferrier
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Circulation, 2008
Calcium homeostasis is critical for cardiac myocyte function and must be tightly regulated. In this study we test the hypothesis that a mobile carboxyl-terminal cleavage product (CCt) of the cardiac L-type calcium channel (Ca V 1.2) auto-regulates expression.
Elizabeth A Schroder +2 more
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Calcium homeostasis is critical for cardiac myocyte function and must be tightly regulated. In this study we test the hypothesis that a mobile carboxyl-terminal cleavage product (CCt) of the cardiac L-type calcium channel (Ca V 1.2) auto-regulates expression.
Elizabeth A Schroder +2 more
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L-Type Calcium Channel Recording
2006Calcium channels constitute a large family of voltageand ligand-operated ionchannels. They share several structural similarities with voltage-gated Naand K-channels. All three channel populations appear to originate from the same gene superfamily. Ca channels are ubiquitous, they can be found in almost any type of excitable and most unexcitable cells ...
Uta C. Hoppe +3 more
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Molecular Pharmacology of Non-L-type Calcium Channels
Current Pharmaceutical Design, 2005Voltage-gated calcium channels are key sources of calcium entry into the cytosol. Mutations in calcium channels have been implicated in numerous disorders such as migraine, incomplete congenital X-linked stationary night blindness, epilepsy, and ataxia, and they are important therapeutic targets for the treatment of pain, stroke, hypertension, and ...
Clinton J, Doering, Gerald W, Zamponi
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The Biochemical Properties of L-Type Calcium Channels
Journal of Cardiovascular Pharmacology, 1988Activation of the cardiac beta-adrenergic receptor stimulates cAMP levels and activates cAMP-dependent protein kinase. The kinase phosphorylates the calcium channel and enhances thereby the availability and the number of channels that are opened during depolarization. The increased calcium influx leads then to a positive inotropic response. The calcium
F, Hofmann +3 more
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Hormones and Behavior, 2008
Both opioids and calcium channel blockers could affect hypothalamic-pituitary-adrenal (HPA) axis function. Nifedipine, as a calcium channel blocker, can attenuate the development of morphine dependence; however, the role of the HPA axis in this effect has not been elucidated.
Saeed, Esmaeili-Mahani +4 more
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Both opioids and calcium channel blockers could affect hypothalamic-pituitary-adrenal (HPA) axis function. Nifedipine, as a calcium channel blocker, can attenuate the development of morphine dependence; however, the role of the HPA axis in this effect has not been elucidated.
Saeed, Esmaeili-Mahani +4 more
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Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
Nature Cell Biology, 2000A dynamic positive feedback mechanism, known as 'facilitation', augments L-type calcium-ion currents (ICa) in response to increased intracellular Ca2+ concentrations. The Ca2+-binding protein calmodulin (CaM) has been implicated in facilitation, but the single-channel signature and the signalling events underlying Ca2+/CaM-dependent facilitation are ...
I, Dzhura +4 more
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Regulation of the L-type calcium channel
Trends in Pharmacological Sciences, 1987Abstract The voltage-operated L-type calcium channel is regulated by protein phosphorylation and G proteins in a variety of tissues and eukaryotes including non-excitable cells. The 165 kDa protein of the dihydropyridine receptor from rabbit skeletal muscle contains all the regulatory sites of an L-type calcium channel and the calcium conducting unit
Franz Hofmann +4 more
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L-type calcium channels and calcium channel ligands
1992Abstract L-type calcium channels possess high affinity drug binding domains for different chemical classes of calcium channel active drugs. Reversible binding experiments using radiolabeled and fluorescently labeled calcium antagonists revealed tight allosteric coupling between several distinct drug binding domains and divalent cation binding sites ...
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