Results 31 to 40 of about 515,300 (403)

Influx of Calcium through L-type Calcium Channels in Early Postnatal Regulation of Chloride Transporters in the Rat Hippocampus [PDF]

, 2009
During the early postnatal period, GABAB receptor activation facilitates L-type calcium current in rat hippocampus. One developmental process that L-type current may regulate is the change in expression of the K+Cl− co-transporter (KCC2) and N+K+2Cl− co ...
Balakrishnan, Ben-Ari, Ben-Ari, Bettler, Bi, Blaesse, Carter, Cherubini, Davies, Delpire, Dutar, Fiumelli, Fujikawa, Galanopoulou, Ganguly, Gähwiler, Harrison, Hübner, Kahle, Kanaka, Kanaumi, Khazipov, Lambert, Leinekugel, Leinekugel, Leinekugel, Liu, Lu, Mynlieff, Newberry, Nuñez, Owens, Payne, Pfrieger, Plotkin, Rissman, Rivera, Scholz, Shen, Siebler, Stein, Takahashi, Thompson, Vicario-Abejón, Wang, Wu, Yan, Yu, Yuste   +48 more
core   +2 more sources

Conditional Deletion of the L-Type Calcium Channel Cav1.2 in Oligodendrocyte Progenitor Cells Affects Postnatal Myelination in Mice

Journal of Neuroscience, 2016
To determine whether L-type voltage-operated Ca2+ channels (L-VOCCs) are required for oligodendrocyte progenitor cell (OPC) development, we generated an inducible conditional knock-out mouse in which the L-VOCC isoform Cav1.2 was postnatally deleted in ...
V. Cheli, D. A. Santiago González, Tenzing Namgyal Lama, V. Spreuer, V. Handley, G. Murphy, P. Paez   +6 more
semanticscholar   +1 more source

Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II

Behavioral and Brain Functions, 2008
We study the voltage dependent calcium channels and nitric oxide involvement in angiotensin II-induced pressor effect. The antipressor action of L-Type calcium channel antagonist, nifedipine, has been studied when it was injected into the third ventricle
Guarda Ismael FMS, Saad Wilson A, Camargo Luiz AA, Santos Talmir AFB   +3 more
doaj   +1 more source

Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology

Scientific Reports, 2016
Dendritic spines are the postsynaptic compartments of glutamatergic synapses in the brain. Their number and shape are subject to change in synaptic plasticity and neurological disorders including autism spectrum disorders and Parkinson’s disease.
R. Stanika, Marta Campiglio, Alexandra Pinggera, Amy Lee, J. Striessnig, B. Flucher, G. Obermair   +6 more
semanticscholar   +1 more source

Pharmacological characterization of presynaptic calcium currents underlying glutamatergic transmission in the avian auditory brainstem [PDF]

, 1995
We used whole-cell patch-clamp techniques on presynaptic terminals and postsynaptic neurons of the glutamatergic magnocellularis synapse in the chick auditory brainstem to study the effects of N, P, and L-type calcium channel blockers directly on ...
Laurent, Gilles, Sivaramakrishnan, Shobhana   +1 more
core   +1 more source

Differential Involvement of L-Type Calcium Channels in Epileptogenesis of Rat Hippocampal Slices during Ontogenesis

Neurobiology of Disease, 2000
Organic calcium channel antagonists block epileptiform activity in adult tissue, suggesting an essential role of L-type channels in epileptogenesis in the mature CNS.
R. Köhling, H. Straub, E.-J. Speckmann
doaj   +1 more source

Neuroprotective effects of blockers for T-type calcium channels

Molecular Neurodegeneration, 2009
Cognitive and functional decline with age is correlated with deregulation of intracellular calcium, which can lead to neuronal death in the brain.
Lei Debin, Baird Michelle A, Lin-Ye Avary, Wildburger Norelle C, Bao Jianxin   +4 more
doaj   +1 more source

L-type calcium channel auto-regulation of transcription [PDF]

Cell Calcium, 2011
L-type calcium channels (LTCC) impact the function of nearly all excitable cells. The classical LTCC function is to mediate trans-sarcolemmal Ca(2+) flux. This review focuses on the contribution of a mobile segment of the LTCC that regulates ion channel function, and also serves as a regulator of transcription in the nucleus.
Jonathan, Satin, Elizabeth A, Schroder, Shawn M, Crump   +2 more
openaire   +2 more sources

The L-type calcium channel in the heart: the beat goes on.

Journal of Clinical Investigation, 2005
Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+.
I. Bódi, G. Mikala, Sheryl E. Koch, S. Akhter, A. Schwartz   +4 more
semanticscholar   +1 more source

Nonspecific, Reversible Inhibition of Voltage-Gated Calcium Channels by CaMKII Inhibitor CK59 [PDF]

, 2013
Investigation of kinase-related processes often uses pharmacological inhibition to reveal pathways in which kinases are involved. However, one concern about using such kinase inhibitors is their potential lack of specificity.
Kahrls, Andrew S., Mynlieff, Michelle
core   +2 more sources