Results 41 to 50 of about 515,300 (403)

Apoptotic Cell Death and Impairment of L-Type Voltage-Sensitive Calcium Channel Activity in Rat Cerebellar Granule Cells Treated with the Prion Protein Fragment 106–126

Neurobiology of Disease, 2000
Prion diseases are neurodegenerative pathologies characterized by the accumulation, in the brain, of altered forms of the prion protein (PrP), named PrPSc.
Stefano Thellung, Tullio Florio, Valentina Villa, Alessandro Corsaro, Sara Arena, Carolina Amico, Mauro Robello, Mario Salmona, Gianluigi Forloni, Orso Bugiani, Fabrizio Tagliavini, Gennaro Schettini   +11 more
doaj   +1 more source

Vascular Response of Tetrabromobisphenol a in Rat Aorta: Calcium Channels Inhibition and Potassium Channels Activation

Toxics, 2022
Tetrabromobisphenol A (TBBPA) is a flame retardant widely used to reduce flammability. It is an endocrine disruptor, and due to constant human exposure, some concerns have been raised regarding its impact on human health.
Joana Feiteiro, Sandra M. Rocha, Melissa Mariana, Cláudio J. Maia, Elisa Cairrao   +4 more
doaj   +1 more source

The CACNA1F Gene Encodes an L-Type Calcium Channel with Unique Biophysical Properties and Tissue Distribution

Journal of Neuroscience, 2004
Glutamate release from rod photoreceptors is dependent on a sustained calcium influx through L-type calcium channels. Missense mutations in the CACNA1F gene in patients with incomplete X-linked congenital stationary night blindness implicate the Cav1.4 ...
J. McRory, J. Hamid, C. Doering, Esperanza García, R. Parker, Kevin S. Hamming, Lina Chen, Michael E. Hildebrand, Aaron M. Beedle, L. Feldcamp, G. Zamponi, T. Snutch   +11 more
semanticscholar   +1 more source

Responsiveness of voltage-gated calcium channels in SH-SY5Y human neuroblastoma cells on quasi-three-dimensional micropatterns formed with poly (l-lactic acid) [PDF]

, 2013
Introduction: In this study, quasi-three-dimensional (3D) microwell patterns were fabricated with poly (l-lactic acid) for the development of cell-based assays, targeting voltage-gated calcium channels (VGCCs).
An, Zhi-Xing, Huang, Qi-Ping, Jin, Liang, Kisaalita, William S., Li, Chen-Zhong, Liao, Yan-Jian, Luo, Mei-Rong, Wang, Zheng-Wei, Wu, Ze-Zhi, Zhang, Li-Guang, Zhong, Dong-Huo   +10 more
core   +1 more source

Ionic Mechanisms of Disopyramide Prolonging Action Potential Duration in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1

Frontiers in Pharmacology, 2020
Short QT syndrome (SQTS) is associated with tachyarrhythmias and sudden cardiac death. So far, only quinidine has been demonstrated to be effective in patients with SQTS type 1(SQTS1).
Huan Lan, Qiang Xu, Qiang Xu, Ibrahim El-Battrawy, Ibrahim El-Battrawy, Rujia Zhong, Xin Li, Siegfried Lang, Siegfried Lang, Lukas Cyganek, Lukas Cyganek, Martin Borggrefe, Martin Borggrefe, Xiaobo Zhou, Xiaobo Zhou, Xiaobo Zhou, Ibrahim Akin, Ibrahim Akin   +17 more
doaj   +1 more source

Effects of early afterdepolarizations on excitation patterns in an accurate model of the human ventricles [PDF]

, 2017
Early Afterdepolarizations, EADs, are defined as the reversal of the action potential before completion of the repolarization phase, which can result in ectopic beats.
Panfilov, Alexander, Seemann, Gunnar, Van Nieuwenhuyse, Enid, Vandersickel, Nele   +3 more
core   +3 more sources

Effect of iron overload on electrophysiology of slow reaction autorhythmic cells of left ventricular outflow tract in guinea pigs

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To investigate the electrophysiology effects and mechanism of iron overload on the slow response autorhythmic cells in the left ventricular outflow tract of guinea pigs.
Ling Fan, Li-Feng Chen, Jing Fan, Lan-Ping Zhao, Xiao-Yun Zhang   +4 more
doaj   +1 more source

Vitamin D Hormone Confers Neuroprotection in Parallel with Downregulation of L-Type Calcium Channel Expression in Hippocampal Neurons

Journal of Neuroscience, 2001
Although vitamin D hormone (VDH; 1,25-dihydroxyvitamin D3), the active metabolite of vitamin D, is the major Ca2+-regulatory steroid hormone in the periphery, it is not known whether it also modulates Ca2+ homeostasis in brain neurons.
Lawrence D. Brewer, Véronique Thibault, K. Chen, M. Langub, P. Landfield, N. Porter   +5 more
semanticscholar   +1 more source

Minimal state models for ionic channels involved in glucagon secretion

Mathematical Biosciences and Engineering, 2010
Pancreatic alpha cells synthesize and release glucagon. This hormone along with insulin, preserves blood glucose levels within a physiological range. During low glucose levels, alpha cells exhibit electrical activity related to glucagon secretion.In this
Virginia González-Vélez, Amparo Gil, Iván Quesada   +2 more
doaj   +1 more source

Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression

Nature Communications, 2016
Calcium signalling plays a critical role in the pathogenesis of heart failure. Here we describe a cardiac protein named Myoscape/FAM40B/STRIP2, which directly interacts with the L-type calcium channel.
M. Eden, B. Meder, M. Völkers, Montatip Poomvanicha, Katrin Domes, M. Branchereau, P. Marck, Rainer Will, A. Bernt, A. Rangrez, M. Busch, Thure Dirk H. Juan Markus Alexander Holger Cornelia Jerz Adler Busch Antonio Aguilar-Pimentel Ollert Götz S, T. Adler, D. Busch, Juan Antonio Aguilar-Pimentel, M. Ollert, Alexander A. Götz, H. Schulz, C. Prehn, J. Adamski, L. Becker, T. Klopstock, M. Horsch, J. Beckers, A. Schrewe, R. Bekeredjian, H. Katus, L. Garrett, S. Hölter, W. Wurst, O. Puk, J. Graw, W. Hans, J. Rozman, M. Klingenspor, F. Neff, Monica Tost, J. Calzada-Wack, Tanja Klein-Rodewald, I. Rácz, A. Zimmer, B. Rathkolb, Eckhard Wolf, C. Lengger, H. Maier, Claudia Stoeger, S. Leuchtenberger, V. Gailus-Durner, H. Fuchs, M. Hrabě de Angelis, C. Heymes, W. Rottbauer, P. Most, F. Hofmann, N. Frey   +54 more
semanticscholar   +1 more source