Results 51 to 60 of about 515,300 (403)

Metabotropic Ca2+ channel-induced Ca2+ release and ATP-dependent facilitation of arterial myocyte contraction [PDF]

, 2006
Voltage-gated Ca2_ channels in arterial myocytes can mediate Ca2_ release from the sarcoplasmic reticulum and, thus, induce contraction without the need of extracellular Ca2_ influx.
Calderón Sánchez, Eva María, López Barneo, José, Ordóñez Guerrero, Antonio, Ruiz Pérez, Myriam, Ureña López, Juan, Valle Rodríguez, Alberto del   +5 more
core   +2 more sources

Anomalous L-Type Calcium Channels of Rat Spinal Motoneurons [PDF]

The Journal of General Physiology, 1999
Single channel patch-clamp recordings show that embryonic rat spinal motoneurons express anomalous L-type calcium channels, which reopen upon repolarization to resting potentials, displaying both short and long reopenings. The probability of reopening increases with increasing voltage of the preceding depolarization without any apparent correlation ...
HIVERT B, LUVISETTO S, NAVANGIONE A, TOTTENE A, PIETROBON, DANIELA   +4 more
openaire   +3 more sources

The calmodulin-binding, short linear motif, NSCaTE is conserved in L-type channel ancestors of vertebrate Cav1.2 and Cav1.3 channels. [PDF]

PLoS ONE, 2013
NSCaTE is a short linear motif of (xWxxx(I or L)xxxx), composed of residues with a high helix-forming propensity within a mostly disordered N-terminus that is conserved in L-type calcium channels from protostome invertebrates to humans.
Valentina Taiakina, Adrienne N Boone, Julia Fux, Adriano Senatore, Danielle Weber-Adrian, J Guy Guillemette, J David Spafford   +6 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice

Frontiers in Cellular Neuroscience, 2015
Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (α1H T-type) calcium channels; KLHL1 knockdown experiments (KD) cause down-regulation of both channel types and altered synaptic properties
Paula Patricia Perissinotti, Elizabeth G. Ethington, Erik eAlmazan, Elizabeth eMartínez-Hernández, Jennifer eKalil, Michael D. Koob, Erika S. Piedras-Renteria, Erika S. Piedras-Renteria   +7 more
doaj   +1 more source

Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6) [PDF]

, 2017
Aims Short QT syndrome (SQTS) is a genetically determined ion-channel disorder, which may cause malignant tachyarrhythmias and sudden cardiac death. Thus far, mutations in five different genes encoding potassium and calcium channel subunits have been ...
Abriel, Hugues, Albesa, Maxime, Antzelevitch, Charles, Barajas-Martinez, Héctor, Baumer, Alessandra, Duru, Firat, Ghadri, Jelena-Rima, Hu, Dan, Kaplan, Vladimir, Lüscher, Thomas F., Puleo, Colleen, Rauch, Anita, Rougier, Jean-Sébastien, Sticht, Heinrich, Templin, Christian   +14 more
core  

Simultaneous mapping of membrane voltage and calcium in zebrafish heart in vivo reveals chamber-specific developmental transitions in ionic currents [PDF]

, 2014
The cardiac action potential (AP) and the consequent cytosolic Ca2+ transient are key indicators of cardiac function. Natural developmental processes, as well as many drugs and pathologies change the waveform, propagation, or variability (between cells ...
Cohen, Adam E., Douglass, Adam D., Engert, Florian, Hou, Jennifer H., Kralj, Joel M.   +4 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Roles of Calcium Ions in Parkinson’s Disease: Calcium Channel Inhibitors as a Novel Agents?

Journal of Molecular Pathology, 2022
Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized by the loss of dopaminergic neurons, which results in motor impairment.
Md Reyaz Alam, Khadga Raj, Shamsher Singh   +2 more
doaj   +1 more source

Identification of Palmitoylation Sites within the L-type Calcium Channel β2a Subunit and Effects on Channel Function*

Journal of Biological Chemistry, 1996
The hydrophilic β2a subunit of the L-type calcium channel was recently shown to be a membrane-localized, post-translationally modified protein (Chien, A. J., Zhao, X. L., Shirokov, R. E., Puri, T. S., Chang, C. F., Sun, D. D., Rios, E., and Hosey, M. M. (
A. Chien, Kristen M Carr, R. Shirokov, E. Ríos, M. Hosey   +4 more
semanticscholar   +1 more source