Results 71 to 80 of about 180,512 (263)

Localized Calcineurin in Calcium- Dependent Inactivation of L-type Calcium Channels [PDF]

, 2010
William A. Sather, Seth F. Oliveria, Mark L. Dell’Acqua   +2 more
openalex   +1 more source

Aging Reduces L-type Calcium Channel Current and the Vasodilatory Response of Small Mesenteric Arteries to Calcium Channel Blockers

Frontiers in Physiology, 2016
Calcium channel blockers are widely used to treat cardiovascular disease (CVD) including hypertension. As aging is an independent risk factor for CVD, the use of calcium channel blockers increases with increasing age.
Sulayma A Albarwani, Fathi eMansour, Abdul Aleem eKhan, Intisar eAl-Lawati, Abdulla eAl-Kaabi, Al-Manar eAl-Busaidi, Safa eAl-Hadhrami, Isehaq eAl-Husseini, Sultan eAl-Siyabi, Musbah O Tanira   +9 more
doaj   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

CaV1.3 L-type calcium channels modulate depression-like behavior in mice independent of deaf phenotype [PDF]

, 2009
Perrine Busquet, Ngoc Khoi Nguyen, Eduard Schmid, Naoyuki Tanimoto, Mathias W. Seeliger, Tamar Ben‐Yosef, Fengxia Mizuno, Abram Akopian, Nicolas Singewald, Jörg Striessnig   +9 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Role of Calcium Channels in the Protective Effect of Hydrogen Sulfide in Rat Cardiomyoblasts

Cellular Physiology and Biochemistry, 2014
Background: Hydrogen sulfide contributes to the reduction of oxidative stress-related injury in cardiomyocytes but the underlying mechanism is still unclear. Aims: Here we investigated the role of voltage-operated calcium channels (VOCCs) as mediators of
Daniele Avanzato, Annalisa Merlino, Sabina Porrera, Rui Wang, Luca Munaron, Daniele Mancardi   +5 more
doaj   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Calcium Influx through L-type Channels Generates Protein Kinase M to Induce Burst Firing of Dopamine Cells in the Rat Ventral Tegmental Area [PDF]

, 2007
Yudan Liu, Jules J.E. Doré, Xihua Chen
openalex   +1 more source

Electrophysiological Mechanism of Catestatin Antiarrhythmia: Enhancement of Ito, IK, and IK1 and Inhibition of ICa‐L in Rat Ventricular Myocytes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiovascular disease remains one of the leading causes of death globally. Myocardial ischemia and infarction, in particular, frequently cause disturbances in cardiac electrical activity that can trigger ventricular arrhythmias.
Ying Zhang, Hua Chen, Qingmin Ma, Hui Jia, Hongyu Ma, Zishuo Du, Yan Liu, Xiangjian Zhang, Yi Zhang, Yue Guan, Huijie Ma   +10 more
doaj   +1 more source