Results 81 to 90 of about 515,300 (403)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology

Communications Biology, 2023
An in vitro model of hypertrophic cardiomyopathy is developed and used to identify a structural-functional link between the L-type calcium channel, mitochondria and the extracellular matrix.
Helena M. Viola, Caitlyn Richworth, Tanya Solomon, Ian L. Chin, Henrietta Cserne Szappanos, Srinivasan Sundararaj, Dmitry Shishmarev, Marco G. Casarotto, Yu Suk Choi, Livia C. Hool   +9 more
doaj   +1 more source

Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes [PDF]

, 2017
Objective: Although aldosterone has been implicated in the pathogenesis of cardiac hypertrophy and heart failure, its cellular mechanism of action on cardiomyocyte function is not yet completely elucidated.
Barrère-Lemaire, Stéphanie, Bénitah, Jean-Pierre, Lalevé, Nathalie, Nargeot, Joël, Perrier, Emeline, Rebsamen, Michela C., Rossier, Michel F.   +6 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Advanced Atrioventricular Block in Athletes: Prevalence and Role of Anti‐Ro/Sjögren Syndrome–Related Antigen A Antibodies

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Advanced atrioventricular block (AVB), that is, higher than second‐degree Mobitz‐1, is an abnormal finding in athletes. Despite intensive investigation, in several cases the pathogenesis remains unknown, but frequently pacemaker implantation ...
Pietro Enea Lazzerini, Iacopo Bertolozzi, Alessandra Cartocci, Vamsi Krishna Murthy Ginjupalli, Pietro Alberto Teneggi, Davide Pica, Giovanni Merico, Irene Bogazzi, Viola Salvini, Riccardo Accioli, Fabio Salvadori, Tommaso Marzotti, Gabriele Cevenini, Matteo Capecchi, Silvia Cantara, Anna Cantore, Maria Infantino, Stefania Bisogno, Francesco Finizola, Flavio D'ascenzi, Franco Laghi‐Pasini, Maurizio Acampa, Pier Leopoldo Capecchi, Mohamed Boutjdir   +23 more
doaj   +1 more source

Prenatal Hypoxia Induced Dysfunction in Cerebral Arteries of Offspring Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundHypoxia during pregnancy could cause abnormal development and lead to increased risks of vascular diseases in adults. This study determined angiotensin II (AII)‐mediated vascular dysfunction in offspring middle cerebral arteries (MCA).
Jiaqi Tang, Na Li, Xueyi Chen, Qinqin Gao, Xiuwen Zhou, Yingying Zhang, Bailin Liu, Miao Sun, Zhice Xu   +8 more
doaj   +1 more source

Cytosolic peptides encoding CaV1 C-termini downregulate the calcium channel activity-neuritogenesis coupling

Communications Biology, 2022
When present in the cytosol, a variety of peptides encoded by the distal carboxyl-termini of the L-type CaV1 calcium channels downregulate channel activity and neurite outgrowth.
Yaxiong Yang, Zhen Yu, Jinli Geng, Min Liu, Nan Liu, Ping Li, Weili Hong, Shuhua Yue, He Jiang, Haiyan Ge, Feng Qian, Wei Xiong, Ping Wang, Sen Song, Xiaomei Li, Yubo Fan, Xiaodong Liu   +16 more
doaj   +1 more source

Amyloid Precursor Protein Regulates Cav1.2 L-type Calcium Channel Levels and Function to Influence GABAergic Short-Term Plasticity

Journal of Neuroscience, 2009
Amyloid precursor protein (APP) has been strongly implicated in the pathogenesis of Alzheimer's disease (AD). Although impaired synaptic function is believed to be an early and causative event in AD, how APP physiologically regulates synaptic properties ...
Li Yang, Zilai Wang, Baiping Wang, N. Justice, Hui Zheng   +4 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Inactivation of L-type calcium channel modulated by HCN2 channel

American Journal of Physiology-Cell Physiology, 2010
Ca2+ entry is delicately controlled by inactivation of L-type calcium channel (LTCC) composed of the pore-forming subunit α1C and the auxiliary subunits β1 and α2δ. Calmodulin is the key protein that interacts with the COOH-terminal motifs of α1C, leading to the fine control of LTCC inactivation. In this study we show evidence that a hyperpolarization-
Yen-Chang, Lin, Jianying, Huang, Qi, Zhang, John M, Hollander, Jefferson C, Frisbee, Karen H, Martin, Casey, Nestor, Robert, Goodman, Han-Gang, Yu   +8 more
openaire   +3 more sources