Results 111 to 120 of about 346,828 (310)

Retinoschisin Facilitates the Function of L-Type Voltage-Gated Calcium Channels

Frontiers in Cellular Neuroscience, 2017
Modulation of ion channels by extracellular proteins plays critical roles in shaping synaptic plasticity. Retinoschisin (RS1) is an extracellular adhesive protein secreted from photoreceptors and bipolar cells, and it plays an important role during ...
Liheng Shi, Michael L. Ko, Gladys Y.-P. Ko, Gladys Y.-P. Ko   +3 more
doaj   +1 more source

Synthesis and Effects of Novel Dihydropyridines as Dual Calcium Channel Blocker and Angiotensin Antagonist on Isolated Rat Aorta [PDF]

, 2009
Four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. The effects of 5a and 5b on angiotensin receptors (AT1) and L-type calcium channels were investigated on isolated rat aorta.
Farzin Hadizadeh, Mohsen Imenshahidi, Morteza Taghiabadi, Payman Esmaili   +3 more
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Dysrhythmia due to Verapamil Overdose in a Young Woman

Case Reports in Cardiology
Verapamil (VER) is characterized as a calcium channel blocker (CCB) that can be intentionally or unintentionally overdosed. This drug, like other CCBs, inhibits the entry of calcium into vascular and myocardial tissues through L-type channels. VER exerts
Abdollah Malakian, Ensiyeh Taghizadeh, Zakaria Zakariaei   +2 more
doaj   +1 more source

Clustering of Ca_V 1.3 L-type calcium channels by Shank3. [PDF]

J Neurochem, 2023
Yang Q, Perfitt TL, Quay J, Hu L, Lawson-Qureshi D, Colbran RJ.   +5 more
europepmc   +1 more source

Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons [PDF]

, 1990
A method for clamping cytosolic free Ca2+ ([Ca2+]i) in cultures of rat sympathetic neurons at or below resting levels for several days was devised to determine whether Ca2+ signals are required for neurite outgrowth from neurons that depend on Nerve ...
Murrell, R D, Suidan, H S, Tolkovsky, A M, Walker, A E   +3 more
core   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Nitric oxide signalling augments neuronal voltage-gated L-type (Ca(v)1) and P/q-type (Ca(v)2.1) channels in the mouse medial nucleus of the trapezoid body.

PLoS ONE, 2012
Nitric Oxide (NO) is a diffusible second messenger that modulates ion channels, intrinsic excitability and mediates synaptic plasticity. In light of its activity-dependent generation in the principal neurons of the medial nucleus of the trapezoid body ...
Adam J B Tozer, Ian D Forsythe, Joern R Steinert   +2 more
doaj   +1 more source

Characterization of two pathological gating-charge substitutions in Cav1.4 L-type calcium channels. [PDF]

Channels (Austin), 2023
Heigl T, Netzer MA, Zanetti L, Ganglberger M, Fernández-Quintero ML, Koschak A.   +5 more
europepmc   +1 more source

Overexpressed Cavbeta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of 'ultra-slow' and 'closed-state' inactivation [PDF]

, 2004
It has been shown that beta auxiliary subunits increase current amplitude in voltage-dependent calcium channels. In this study, however, we found a novel inhibitory effect of beta3 subunit on macroscopic Ba2+ currents through recombinant N- and R-type ...
Adams, DJ, Lewis, R, Yasuda, T
core