Results 71 to 80 of about 346,828 (310)

Developmental synaptic changes at the transient olivocochlear-inner hair cell synapse [PDF]

, 2019
In the mature mammalian cochlea, inner hair cells (IHCs) are mainly innervated by afferent fibers that convey sound information to the CNS. During postnatal development, however, medial olivocochlear (MOC) efferent fibers transiently innervate the IHCs ...
Elgoyhen, Ana Belen, Katz, Eleonora, Kearney, Graciela Inés, Vattino, Lucas Gabriel, Wedemeyer, Carolina, Zorrilla de San Martín, Javier   +5 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Role of Calcium Channels in the Protective Effect of Hydrogen Sulfide in Rat Cardiomyoblasts

Cellular Physiology and Biochemistry, 2014
Background: Hydrogen sulfide contributes to the reduction of oxidative stress-related injury in cardiomyocytes but the underlying mechanism is still unclear. Aims: Here we investigated the role of voltage-operated calcium channels (VOCCs) as mediators of
Daniele Avanzato, Annalisa Merlino, Sabina Porrera, Rui Wang, Luca Munaron, Daniele Mancardi   +5 more
doaj   +1 more source

Cellular Calcium Regulation in Hypertension [PDF]

, 2017
In vascular muscle cells, two distinct types of functionally important calcium (Ca2++) channels, called transient (T) and sustained (L), are differentiated by dihydropyridine calcium antagonists (CaA).
Erne, P., Hermsmeyer, K.
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels. [PDF]

PLoS ONE, 2016
The process of calcium entry in T cells is a multichannel and multi-step process. We have studied the requirement for L-type calcium channels (Cav1.1) α1S subunits during calcium entry after TCR stimulation. High expression levels of Cav1.1 channels were
Didi Matza, Abdallah Badou, Kathryn G Klemic, Judith Stein, Usha Govindarajulu, Monica J Nadler, Jean-Pierre Kinet, Amnon Peled, Oz M Shapira, Leonard K Kaczmarek, Richard A Flavell   +10 more
doaj   +1 more source

Inactivation of L-type calcium channel modulated by HCN2 channel

American Journal of Physiology-Cell Physiology, 2010
Ca2+ entry is delicately controlled by inactivation of L-type calcium channel (LTCC) composed of the pore-forming subunit α1C and the auxiliary subunits β1 and α2δ. Calmodulin is the key protein that interacts with the COOH-terminal motifs of α1C, leading to the fine control of LTCC inactivation. In this study we show evidence that a hyperpolarization-
Yen-Chang, Lin, Jianying, Huang, Qi, Zhang, John M, Hollander, Jefferson C, Frisbee, Karen H, Martin, Casey, Nestor, Robert, Goodman, Han-Gang, Yu   +8 more
openaire   +3 more sources

Effects of methamphetamine on locomotor activity and thalamic gene expression in leptin-deficient obese mice [PDF]

, 2017
Leptin is an adipose-derived hormone that regulates energy balance. Leptin receptors are expressed in extrahypothalamic sites and several reports showed that leptin can influence feeding and locomotor behavior via direct actions on dopaminergic neurons ...
Bisagno, Veronica, Gonzalez, Betina, Gonzalez, Candela Rocio, Urbano Suarez, Francisco Jose   +3 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Apoptotic Cell Death and Impairment of L-Type Voltage-Sensitive Calcium Channel Activity in Rat Cerebellar Granule Cells Treated with the Prion Protein Fragment 106–126

Neurobiology of Disease, 2000
Prion diseases are neurodegenerative pathologies characterized by the accumulation, in the brain, of altered forms of the prion protein (PrP), named PrPSc.
Stefano Thellung, Tullio Florio, Valentina Villa, Alessandro Corsaro, Sara Arena, Carolina Amico, Mauro Robello, Mario Salmona, Gianluigi Forloni, Orso Bugiani, Fabrizio Tagliavini, Gennaro Schettini   +11 more
doaj   +1 more source