Results 81 to 90 of about 346,828 (310)

Modeling L-type Calcium Channel with Dihydropyridines [PDF]

Biophysical Journal, 2009
Dyhydropyridines (DHPs) is a major class of L-type calcium channel (LCC) ligands, which have boat-like six-membered ring with NH-group at the stern, aromatic moiety at the bow, and various substituents at the port and starboard sides. DHPs demonstrate antagonistic or agonistic action, which was previously explained as stabilization or destabilization ...
Tikhonov, Denis B., Zhorov, Boris S.
openaire   +1 more source

Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]

, 2009
The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Voltage-gated calcium channels: Their discovery, function and importance as drug targets

Brain and Neuroscience Advances, 2018
This review will first describe the importance of Ca 2+ entry for function of excitable cells, and the subsequent discovery of voltage-activated calcium conductances in these cells.
Annette C. Dolphin
doaj   +1 more source

Simultaneous mapping of membrane voltage and calcium in zebrafish heart in vivo reveals chamber-specific developmental transitions in ionic currents [PDF]

, 2014
The cardiac action potential (AP) and the consequent cytosolic Ca2+ transient are key indicators of cardiac function. Natural developmental processes, as well as many drugs and pathologies change the waveform, propagation, or variability (between cells ...
Cohen, Adam E., Douglass, Adam D., Engert, Florian, Hou, Jennifer H., Kralj, Joel M.   +4 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Amplification of a calcium channel subunit CACNG4 increases breast cancer metastasis

EBioMedicine, 2020
Background: Previously, we found that amplification of chromosome 17q24.1-24.2 is associated with lymph node metastasis, tumour size, and lymphovascular invasion in invasive ductal carcinoma.
Nisha Kanwar, Katia Carmine-Simmen, Ranju Nair, Chunjie Wang, Soode Moghadas-Jafari, Heiko Blaser, Danh Tran-Thanh, Dongyu Wang, Peiqi Wang, Jenny Wang, Adrian Pasculescu, Alessandro Datti, Tak Mak, John D. Lewis, Susan J. Done   +14 more
doaj   +1 more source

A computational model of excitation and contraction in uterine myocytes from the pregnant rat [PDF]

, 2018
Aberrant uterine myometrial activities in humans are major health issues. However, the cellular and tissue mechanism(s) that maintain the uterine myometrium at rest during gestation, and that initiate and maintain long-lasting uterine contractions during
A Matthew, AV Shmigol, AV Shmigol, B Bengtsson, BM Sanborn, C Martin, CM Hai, GK Swamy, H Kuriyama, HC Parkington, J Atia, J Christoph, J Hering, J Landa, J Xu, J Yang, J-A Hanley, JF King, JR Serrano, K Noble, K Okabe, L Bursztyn, M Alotaibi, M Yoshino, MJ Taggart, Q Ma, RC Young, RM Tribe, S Arrowsmith, S Arrowsmith, S Beck, S Maigaard, S Rihana, S Wray, S Wray, T Burdyga, VG Fast, W-C Tong, W-C Tong, WJEP Lammers, X Wu, Y Inoue, Y Inoue, Y Inoue   +43 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Electrophysiological Mechanisms and Therapeutic Potential of Calcium Channels in Atrial Fibrillation

Reviews in Cardiovascular Medicine
Atrial fibrillation (AF) is a prevalent and complex arrhythmia for which the pathogenesis involves various electrophysiological factors, notably the regulation of calcium channels.
Zuyuan Huang, Cheng Luo, Zimin Wu, Baoshi Zheng   +3 more
doaj   +1 more source