Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite
Abstract Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular glycoproteins produced by the parasite and regarded as a major virulence factor in the neglected tropical ...
Priyanka Bose +4 more
wiley +1 more source
Leishmania braziliensis: Strain-Specific Modulation of Phagosome Maturation
Leishmania (Viannia) braziliensis is responsible for the largest number of American tegumentary leishmaniasis (ATL) in Brazil. ATL can present several clinical forms including typical (TL) and atypical (AL) cutaneous and mucocutaneous (ML) lesions.
Tamara da Silva Vieira +7 more
doaj +1 more source
Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
Maria Eduarda da Veiga Oliveira +3 more
wiley +1 more source
L. braziliensis protein query set.
L. braziliensis protein query set.
Rafael Tosta (728897) +7 more
core +1 more source
Immunity to Lutzomyia whitmani Saliva Protects against Experimental Leishmania braziliensis Infection. [PDF]
Previous works showed that immunization with saliva from Lutzomyia intermedia, a vector of Leishmania braziliensis, does not protect against experimental infection. However, L.
Regis Gomes +9 more
doaj +1 more source
Modelling Palaeodistributions in Marine Environments: A Review
ABSTRACT Aim This scoping review (ScR) synthesises the current literature on the application of Species Distribution Models (SDM) to past marine environments. We assess how these models have been used to reconstruct past environmental suitability, track biogeographical shifts and investigate long‐term ecological dynamics, while identifying key ...
Sarah Mathilde Salomé Beauvais +6 more
wiley +1 more source
Lissothuria braziliensis (Théel, 1886) (Figure 15) Psolus braziliensis Théel, 1886: 15, fig. 7. Thyonepsolus braziliensis: Deichmann 1930: 192, pl. XXI, figs 1–6; Deichmann 1954: 40; Clark 1933: 117. Lissothuria braziliensis: Pawson 1967: 8–10,
Manso, Cynthia Lara De Castro +2 more
core +1 more source
Inhibitory activity of pentacyano(isoniazid)ferrate(II), IQG-607, against promastigotes and amastigotes forms of Leishmania braziliensis. [PDF]
M. tuberculosis and parasites of the genus Leishmania present the type II fatty acid biosynthesis system (FASII). The pentacyano(isoniazid)ferrate(II) compound, named IQG-607, inhibits the enzyme 2-trans-enoyl-ACP(CoA) reductase from M.
Camila F Amorim +10 more
doaj +1 more source
Tegumentary Leishmaniasis Associated With Immune Reconstitution in an HIV Patient—A Case Report
ABSTRACT HIV‐associated Immune Reconstitution Inflammatory Syndrome (IRIS) may significantly alter the immunopathological presentation of American Tegumentary Leishmaniasis (ATL), occasionally causing paradoxical clinical exacerbations. We report the long‐term follow‐up of a 39‐year‐old female coinfected with HIV and disseminated mucocutaneous ...
Marilia Brasil Xavier +9 more
wiley +1 more source
Knowledge mapping of risk mitigation measures against vector‐borne diseases
Abstract A comprehensive synthesis of current evidence on surveillance, prevention and control measures for 25 selected vector‐borne diseases (VBDs) affecting animals in the EU is presented here. The assessment integrates evidence from systematic literature reviews, modelling studies, field investigations and expert judgement.
European Food Safety Authority (EFSA) +8 more
wiley +1 more source

