Results 51 to 60 of about 9,297 (211)

Development of a multilocus microsatellite typing approach for discriminating strains of Leishmania (Viannia) species.

, 2009
A multilocus microsatellite typing (MLMT) approach based on the analysis of 15 independent loci has been developed for the discrimination of strains belonging to different Viannia species.
Espinosa, Diego, Oddone, Rolando, Arevalo, Jorge, Mauricio, Isabel, Schweynoch, Carola, Sousa, Cintia dos Santos de, Kuhls, Katrin, de Sousa, Cintia dos Santos, Cupolillo, Elisa, Schönian, Gabriele, Noyes, Harry   +10 more
core   +1 more source

IL‐17 and Regulatory Cytokines (IL‐10 and IL‐27) in L. braziliensis Infection [PDF]

Parasite Immunology, 2011
AbstractCutaneous leishmaniasis (CL) is characterized by high production of pro‐inflammatory cytokines and development of pathology. Individuals with subclinical L. braziliensis infection (SC) have a positive skin test to leishmania, but do not develop disease.
R, Novoa, O, Bacellar, M, Nascimento, T M, Cardoso, R, Ramasawmy, W N, Oliveira, A, Schriefer, E M, Carvalho   +7 more
openaire   +2 more sources

Infection of Human Monocytes with Leishmania infantum Strains Induces a Downmodulated Response when Compared with Infection with Leishmania braziliensis

Frontiers in Immunology, 2018
Human infection with different species of Leishmania leads to distinct clinical manifestations, ranging from relatively mild cutaneous (Leishmania braziliensis) to severe visceral (Leishmania infantum) forms of leishmaniasis.
Agostinho Gonçalves Viana, Luísa Mourão Dias Magalhães, Rodolfo Cordeiro Giunchetti, Walderez O. Dutra, Walderez O. Dutra, Kenneth J. Gollob, Kenneth J. Gollob, Kenneth J. Gollob   +7 more
doaj   +1 more source

Population structure and evidence for both clonality and recombination among Brazilian strains of the subgenus Leishmania (Viannia). [PDF]

PLoS Neglected Tropical Diseases, 2013
Parasites of the subgenus Leishmania (Viannia) cause varying clinical symptoms ranging from cutaneous leishmaniases (CL) with single or few lesions, disseminated CL (DL) with multiple lesions to disfiguring forms of mucocutaneous leishmaniasis (MCL).
Katrin Kuhls, Elisa Cupolillo, Soraia O Silva, Carola Schweynoch, Mariana Côrtes Boité, Maria N Mello, Isabel Mauricio, Michael Miles, Thierry Wirth, Gabriele Schönian   +9 more
doaj   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Clonagem e expressão da enzina tripanotiona redutase de Leishmania braziliensis e atividade leishmanicida de chalconas [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Programa de Pós-graduação em Biotecnologia, Florianópolis, 2011O presente estudo teve por objetivo avaliar atividade leishmanicida in vitro de chalconas trimetoxiladas contra formas ...
Nunes, Rebeca Körting
core  

Leishmania isoenzyme polymorphisms in Ecuador: Relationships with geographic distribution and clinical presentation

, 2006
Background: Determinants of the clinical presentation of the leishmaniases are poorly understood but Leishmania species and strain differences are important.
Cooper Philip J, Masataka Korenaga, Marco Jorge D, Korenaga, Masataka, Rodrigo X Armijos, Hirotomo Kato, Paola A Barroso, Kato Hirotomo, Korenaga, M, Gomez, EA, Calvopina Manuel, Kato, Hirotomo, Hiroshi Uezato, Barroso, Paola A., Armijos, Rodrigo X., Cooper, PJ, Yoshihisa Hashiguchi, Shigeo Nonaka, Nonaka Shigeo, Gomez Eduardo A, Manuel Calvopina, Marco, Jorge D., Kato, H, Barroso Paola A, Mimori, Tatsuyuki, Armijos, RX, Hashiguchi, Y, Nonaka, Shigeo, Eduardo A Gomez, Calvopina, M, Marco, JD, Korenaga Masataka, Tatsuyuki Mimori, Uezato, H, Jorge D Marco, Gomez, Eduardo A., Calvopina, Manuel, Mimori Tatsuyuki, Manuel Calvopina, Uezato Hiroshi, Cooper, Philip J., Hashiguchi, Yoshihisa, Mimori, T, Philip J Cooper, Nonaka, S, Uezato, Hiroshi, Armijos Rodrigo X, Barroso, PA, Hashiguchi Yoshihisa   +48 more
core   +1 more source

In vitro evaluation and in vivo efficacy of nitroimidazole‑sulfanyl ethyl derivatives against Leishmania (V.) braziliensis and Leishmania (L.) mexicana

, 2021
The aim of this study was to synthesize several small molecules of the type 5-nitroimidazole-sulfanyl and evaluate biological properties against the main Leishmania species that cause cutaneous leishmaniasis in Venezuela.
Charris, Jaime E., Oviedo, Henry J., Rodríguez, Noris M., Charris, Jaime, Blanco, Zuleima, Mijares, Michael R., Ramírez, Hegira, Fernández Moreira, Esteban   +7 more
core   +1 more source

Zymodeme and Serodeme Characterization of Leishmania Isolates Obtained from Costa Rican Patients [PDF]

Memorias do Instituto Oswaldo Cruz, 1998
Thirty-four Leishmania isolates obtained from Costa Rican patients, from different geographical areas, were characterized by isoenzyme electrophoresis and indirect immunofluorescense with monoclonal antibodies.
Johnny Peraza, Andrea Urbina, Rodrigo Zeledón   +2 more
doaj   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source