Results 71 to 80 of about 567,009 (289)

Understanding the (Post-)National L1 Subjects: Three Problematics

, 2020
This chapter seeks to develop some of the conceptual work in the field, drawing selectively on the body of scholarship addressed to L1 education and the L1 subjects over the past four decades. It is principally concerned with what are identified as three
Per-Olof Erixon, Bill Green, Erixon, Per-Olof,, Green, Bill,   +3 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Public Sector Transformation in Emerging Economies: Factors Affecting Change Adoption in Pakistan

Administrative Sciences
Organizational change remains a significant challenge in developing countries, often hindered by entrenched bureaucratic cultures and resistance to reform. This study investigates the key determinants of change acceptance among public sector employees in
Muhammad Kamran Nawaz, Ahmed Eltweri, Khalid Abbas, Wa’el Al-Karaki, Farag Edghiem, Scott Foster, Munir Adali   +6 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

On the dual of a mixed H2/l1 optimisation problem

, 2006
The general discrete-time Single-Input Single-Output (SISO) mixed H2/l1 control problem is considered in this paper. It is found that the existing results of duality theory cannot be directly applied to this infinite dimension optimisation problem.
Chu, J., Wu, J., Chen, S.
core  

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

THE RECOMBINANT ANTIGENS FOR VACCINES FOR THE TREATMENT OF PAPILLOMAVIRUS (REVIEW)

Разработка и регистрация лекарственных средств, 2019
Two licensed vaccines Gardasil and Cervarix, containing main capsid protein L1 virus-like particles antigen, are used for prevention of diseases associated with human papilloma virus.
M. A. Zhuchenko
doaj  

Mutations in the extracellular domain of the neural cell adhesion molecule L1 impair protein trafficking in vitro and in vivo

, 2002
Rünker AE. Mutations in the extracellular domain of the neural cell adhesion molecule L1 impair protein trafficking in vitro and in vivo. Bielefeld (Germany): Bielefeld University; 2002.Das neurale Zelladhäsionsmolekül L1 ist ein Mitglied der ...
Rünker, Annette E.
core  

Pioneering of Antibody-Assisted Structure-Based Drug Discovery for PD-L1

, 2023
The principle of antibody-assisted drug discovery aims to use a diverse panel of single domain antibodies (VHH) to identify rare conformational states and/or novel allosteric sites that could modulate function, which may facilitate the discovery of new ...
Tara Kang-Pettinger (15905717)
core   +1 more source

Curricular L1 Disciplinarities: Between Norwegianness and Internationality [PDF]

, 2020
The chapter explores how international impulses may have affected national L1 curricula in Norway from 1939 to 2020. It compares the descriptions of aims and content in seven curricula chronologically, using content analysis. One eye is on changes within
Sigmund Ongstad, Ongstad, Sigmund
core   +1 more source