Results 51 to 60 of about 567,009 (289)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Twenty years of L1: The journal and the research community behind it

, 2021
In 2021, the L1 journal celebrates its 20th anniversary. The editors take this occasion to have a look back to its development and the development of the L1 education research community behind it, and to reflect on prospects for the future.
Araújo, Luisa, Cheong, Choo Mui, Gordon, John, van Rijt, Jimmy, Gourvennec, Aslaug Fodstad, Funke, Reinold   +5 more
core  

Iterative reweighted l1 design of sparse FIR filters [PDF]

, 2012
Sparse FIR filters have lower implementation complexity than full filters, while keeping a good performance level. This paper describes a new method for designing 1D and 2D sparse filters in the minimax sense using a mixture of reweighted l1 minimization
Cristian Rusu, Bogdan Dumitrescu, Dumitrescu, Bogdan, Rusu, Cristian   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Brain development in mice lacking L1–L1 homophilic adhesion [PDF]

The Journal of Cell Biology, 2004
A new mouse line has been produced in which the sixth Ig domain of the L1 cell adhesion molecule has been deleted. Despite the rather large deletion, L1 expression is preserved at normal levels. In vitro experiments showed that L1–L1 homophilic binding was lost, along with L1-α5β1 integrin binding.
Itoh, Kyoko, Cheng, Ling, Kamei, Yoshimasa, Fushiki, Shinji, Kamiguchi, Hiroyuki, Gutwein, Paul, Stoeck, Alexander, Arnold, Bernd, Altevogt, Peter, Lemmon, Vance   +9 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Sissejuhatavalt koolidiskursusest: tekstid ja kirjaoskus neljas õppeaines

Eesti Rakenduslingvistika Ühingu Aastaraamat, 2022
Keelt aineteadmiste vahendajana on hakatud üha enam tähtsustama: paralleelselt kõneldakse keeleteadlikust aineõpetusest ja ainekirjaoskusest. Ainekirjaoskus tähendab ainealase suhtluse harjutamist õpiprotsessi mõlemas otsas – teksti vastuvõtul ja loomel.
Merilin Aruvee
doaj   +1 more source

miR-128 represses L1 retrotransposition by binding directly to L1 RNA [PDF]

Nature Structural & Molecular Biology, 2015
Long interspersed element 1 (LINE-1 or L1) retrotransposons compose 17% of the human genome. Active L1 elements are capable of replicative transposition (mobilization) and can act as drivers of genetic diversity. However, this mobilization is mutagenic and may be detrimental to the host, and therefore it is under strict control.
HAMDORF, Matthias, Idica, A., Zisoulis, D. G., Gamelin, L., Martin, C., Sanders, K. J., Pedersen, I. M.   +6 more
openaire   +3 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source