Results 51 to 60 of about 32,356 (192)

THE RECOMBINANT ANTIGENS FOR VACCINES FOR THE TREATMENT OF PAPILLOMAVIRUS (REVIEW)

Разработка и регистрация лекарственных средств, 2019
Two licensed vaccines Gardasil and Cervarix, containing main capsid protein L1 virus-like particles antigen, are used for prevention of diseases associated with human papilloma virus.
M. A. Zhuchenko
doaj  

Methods of corrosion prevention for steel in marine environments: A review

Results in Surfaces and Interfaces
Corrosion in marine environments poses a challenge for steel and concrete structures due to constant exposure to corrosive elements such as saltwater, oxygen, chlorides, and microorganisms, particularly sulfate-reducing bacteria.
Gabriela Paula Vieira Dalmora, Eron Paulo Borges Filho, Angelo Antonio Maraschin Conterato, William Spenassato Roso, Carlos Eduardo Pereira, Aline Dettmer   +5 more
doaj   +1 more source

miR-128 represses L1 retrotransposition by binding directly to L1 RNA [PDF]

Nature Structural & Molecular Biology, 2015
Long interspersed element 1 (LINE-1 or L1) retrotransposons compose 17% of the human genome. Active L1 elements are capable of replicative transposition (mobilization) and can act as drivers of genetic diversity. However, this mobilization is mutagenic and may be detrimental to the host, and therefore it is under strict control.
HAMDORF, Matthias, Idica, A., Zisoulis, D. G., Gamelin, L., Martin, C., Sanders, K. J., Pedersen, I. M.   +6 more
openaire   +3 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Gender inequalities and academic leadership in Nigeria, South Africa and the United Kingdom: A systematic literature review (2013–2023)

Social Sciences and Humanities Open
This study provides the first systematic review of the literature on women's leadership in higher education in Nigeria, South Africa, and the United Kingdom.
Ayca G. Kaymakcioglu, Michael Thomas
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Public Sector Transformation in Emerging Economies: Factors Affecting Change Adoption in Pakistan

Administrative Sciences
Organizational change remains a significant challenge in developing countries, often hindered by entrenched bureaucratic cultures and resistance to reform. This study investigates the key determinants of change acceptance among public sector employees in
Muhammad Kamran Nawaz, Ahmed Eltweri, Khalid Abbas, Wa’el Al-Karaki, Farag Edghiem, Scott Foster, Munir Adali   +6 more
doaj   +1 more source

What is the source of L1 attrition? The effect of recent L1 re-exposure on Spanish speakers under L1 attrition [PDF]

Bilingualism: Language and Cognition, 2015
The recent hypothesis that L1 attrition affects the ability to process interface structures but not knowledge representations (Sorace, 2011) is tested by investigating the effects of recent L1 re-exposure on antecedent preferences for Spanish pronominal subjects, using offline judgements and online eye-tracking measures.
Chamorro, Gloria, Sorace, Antonella, Sturt, Patrick   +2 more
openaire   +3 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source