Results 31 to 40 of about 567,009 (289)

The Acquisition of L2 Modern Standard Arabic Stress Patterns by L1 Chinese Native Speakers [PDF]

open access: yesMaǧallaẗ Kulliyyaẗ Al-ādāb Ǧāmiʿaẗ Būrsaʿīd, 2022
Chinese learners of Modern Standard Arabic (MSA) as a second language (L2) show many pronunciation difficulties that lead to unintelligible verbal communication with Egyptian native speakers.
منى محمد المعتز بالله مأمون
doaj   +1 more source

PD-L1-Targeted Radionuclide Therapy Combined with αPD-L1 Antibody Immunotherapy Synergistically Improves the Antitumor Effect

open access: yes, 2022
Immune checkpoint blockers (ICBs) targeting programmed death receptor 1 (PD-1) ligand 1 (PD-L1) for immunotherapy have radically reformed oncology. It is of great significance to enhance the response rate of ICB in cancer patients. Here, a radioiodinated
Yiren Zhang (1760983)   +11 more
core   +1 more source

Molecular Backgrounds of ERAP1 Downregulation in Cervical Carcinoma

open access: yesAnalytical Cellular Pathology, 2015
The antigen processing machinery (APM) plays an important role in immune recognition of virally infected and transformed cells. Defective expression of the APM component ERAP1 is associated with progression and poor clinical outcome in cervical carcinoma.
Akash M. Mehta   +4 more
doaj   +1 more source

Competing disciplinarities in curricular L1: A Norwegian case [PDF]

open access: yes, 2015
This article explores historical changes within curricular L1 in search for key mechanisms that can illuminate the role of kinds of disciplinarity in current educational reforms.
Ongstad, Sigmund
core   +2 more sources

The L1 subject in a world of increasing individualism: Democratic paradoxes in Norwegian L1 classrooms [PDF]

open access: yes, 2015
This article examines the subject of first-language (L1) instruction in the student-oriented, democratic Norwegian school. L1 instruction, a humanistic and hermeneutic subject, is closely related to interpretations of everyday life and to everyday ...
Penne, Sylvia, Skarstein, Dag
core   +2 more sources

Investigating the Teachers’ Perceptions toward the Use of L1 in Teaching English

open access: yesIdeas, 2021
This study explores the teachers’ perceptions of using the first language (L1) when teaching English. The conceptual work of literature review is applied as the research method. This means previous works were analysed to investigate teachers’ perceptions
Dodi Widia Nanda
doaj   +1 more source

L1-polysome and L1 RNP complexes in Mael-/- testes.

open access: yes, 2023
(A) Western blot analysis of L1 ORF1p and RPS6 in Mael-/- testicular extracts fractionated through 10–50% sucrose gradients in the presence of cycloheximide (CHX). Fractionated Mael+/- extract served as a negative control.
Chiara De Luca (139084)   +2 more
core   +1 more source

Directed Evolution of PD-L1-Targeted Affibodies by mRNA Display

open access: yes, 2022
Therapeutic monoclonal antibodies directed against PD-L1 (e.g., atezolizumab) disrupt PD-L1:PD-1 signaling and reactivate exhausted cytotoxic T-cells in the tumor compartment.
Brian J. Grindel (9407114)   +10 more
core   +1 more source

The role of L1 use for L1 attrition [PDF]

open access: yes, 2007
While the factor ‘language contact’ is often named among the most important for the development of individual language attrition, empirical validations of this claim are few and far between. This contribution argues that a bilingual’s use of the first language comprises very diverse situations which cannot be subsumed under one predictor variable ...
openaire   +3 more sources

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity

open access: yes, 2009
L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Altevogt, Peter   +6 more
core   +1 more source

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