Results 41 to 50 of about 32,356 (192)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Effects of L1 orthography and L1 phonology on L2 English pronunciation [PDF]

Revue française de linguistique appliquée, 2018
Des recherches récentes ont dévoilé les effets de l’orthographe sur la durée consonantique en anglais L2 de locuteurs natifs italiens (le [p] étant réalisé plus long pour floppy que pour copy ). Nous avons comparé cet effet orthographique avec un effet de la phonologie de la L1 indépendant de l’orthographe, le Voice Onset Time (VOT). La tenue et le VOT
Mairano P., Bassetti B., Sokolovic-Perovic M., Cerni T.   +3 more
openaire   +7 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A Firm’s Market Performance: How Does Sustainability Practice Influence It?

ECONOMICS
The study’s central theme is sustainability practice. It aims to measure the impact of sustainability practices on market performance. The study is quantitative, and data was obtained through a structured questionnaire using a five-point Likert scale ...
Babu Md. Asaduzzaman, Ejaz Faisal, Lina Fatiha Tajnin, Ejaz Sarmad, Islam Md Rohibul, Hassan Md. Khalid, Hossain Md Billal   +6 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Sissejuhatavalt koolidiskursusest: tekstid ja kirjaoskus neljas õppeaines

Eesti Rakenduslingvistika Ühingu Aastaraamat, 2022
Keelt aineteadmiste vahendajana on hakatud üha enam tähtsustama: paralleelselt kõneldakse keeleteadlikust aineõpetusest ja ainekirjaoskusest. Ainekirjaoskus tähendab ainealase suhtluse harjutamist õpiprotsessi mõlemas otsas – teksti vastuvõtul ja loomel.
Merilin Aruvee
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Impact of Covid-19 Pandemic on Financial Innovation, Cashless Society, and Cyber Risk

ECONOMICS, 2022
The global pandemic, as an unprecedented event in the recent past, has significantly changed the modern world. Numerous companies and individuals have faced various challenges that are still present.
Fabris Nikola
doaj   +1 more source

Brain development in mice lacking L1–L1 homophilic adhesion [PDF]

The Journal of Cell Biology, 2004
A new mouse line has been produced in which the sixth Ig domain of the L1 cell adhesion molecule has been deleted. Despite the rather large deletion, L1 expression is preserved at normal levels. In vitro experiments showed that L1–L1 homophilic binding was lost, along with L1-α5β1 integrin binding.
Itoh, Kyoko, Cheng, Ling, Kamei, Yoshimasa, Fushiki, Shinji, Kamiguchi, Hiroyuki, Gutwein, Paul, Stoeck, Alexander, Arnold, Bernd, Altevogt, Peter, Lemmon, Vance   +9 more
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source