Results 11 to 20 of about 178 (92)
Spiroluchuen A‐Synthase: Eine Cyclase aus Aspergillus luchuensis, die ein spirotetracyclisches Diterpen bildet
Angewandte Chemie, Volume 135, Issue 52, December 21, 2023., 2023 Eine Diterpensynthase für Spiroluchuen A mit einem neuartigen Skelett wurde aus Aspergillus luchuensis entdeckt. Enzym‐Engineering durch ortsspezifische Mutagenese ermöglichte die Isolierung von Spiroluchuen B und dem Intermediat Spiroluchuen. Der Enzymmechanismus wurde durch Isotopenmarkierungsexperimente, DFT‐Berechnungen und metadynamische ...Zheng‐Yu Huang, Kizerbo A. Taizoumbe, Chengqin Liang, Bernd Goldfuss, Jian‐He Xu, Jeroen S. Dickschat +5 morewiley +1 more sourceSpiroluchuene A Synthase: A Cyclase from Aspergillus luchuensis Forming a Spirotetracyclic Diterpene
Angewandte Chemie International Edition, Volume 62, Issue 52, December 21, 2023., 2023 A diterpene synthase for spiroluchuene A exhibiting a novel skeleton was discovered from Aspergillus luchuensis. Enzyme engineering through site‐directed mutagenesis allowed for the isolation of spiroluchuene B and the intermediate spiroluchuene. The enzyme mechanism was deeply studied through isotopic labelling experiments, DFT calculations and ...Zheng‐Yu Huang, Kizerbo A. Taizoumbe, Chengqin Liang, Bernd Goldfuss, Jian‐He Xu, Jeroen S. Dickschat +5 morewiley +1 more sourceDominant‐negative variant in SLC1A4 causes an autosomal dominant epilepsy syndrome
Annals of Clinical and Translational Neurology, Volume 10, Issue 6, Page 1046-1053, June 2023., 2023 Abstract
SLC1A4 is a trimeric neutral amino acid transporter essential for shuttling L‐serine from astrocytes into neurons. Individuals with biallelic variants in SLC1A4 are known to have spastic tetraplegia, thin corpus callosum, and progressive microcephaly (SPATCCM) syndrome, but individuals with heterozygous variants are not thought to have disease.Jonai Pujol‐Giménez, Ghayda Mirzaa, Elizabeth E. Blue, Giuseppe Albano, Danny E. Miller, Aimee Allworth, James T. Bennett, Peter H. Byers, Sirisak Chanprasert, Jingheng Chen, Daniel Doherty, Andrew B. Folta, Madelyn A. Gillentine, Ian Glass, Anne Hing, Martha Horike‐Pyne, Kathleen A. Leppig, Azma Parhin, Jane Ranchalis, Wendy H. Raskind, Elisabeth A. Rosenthal, Ulrike Schwarze, Sam Sheppeard, Samuel Strohbehn, Virginia P. Sybert, Andrew Timms, Mark Wener, University of Washington Center for Mendelian Genomics (UW‐CMG)a, Undiagnosed Diseases Network (UDN), Michael J. Bamshad, Suzanne M. Leal, Deborah A. Nickerson, Peter Anderson, Tamara J. Bacus, Elizabeth E. Blue, Katherine Brower, Kati J. Buckingham, Jessica X. Chong, Diana Cornejo Sánchez, Colleen P. Davis, Chayna J. Davis, Christian D. Frazar, Katherine Gomeztagle‐Burgess, William W. Gordon, Martha Horike‐Pyne, Jameson R. Hurless, Gail P. Jarvik, Eric Johanson, J. Thomas Kolar, Colby T. Marvin, Sean McGee, Daniel J. McGoldrick, Betselote Mekonnen, Patrick M. Nielsen, Karynne Patterson, Aparna Radhakrishnan, Matthew A. Richardson, Gwendolin T. Roote, Erica L. Ryke, Isabelle Schrauwen, Kathryn M. Shively, Joshua D. Smith, Monica Tackett, Gao Wang, Jeffrey M. Weiss, Marsha M. Wheeler, Qian Yi, Xiaohong Zhang, Maria T. Acosta, Margaret Adam, David R. Adams, Raquel L. Alvarez, Justin Alvey, Laura Amendola, Ashley Andrews, Euan A. Ashley, Carlos A. Bacino, Guney Bademci, Ashok Balasubramanyam, Dustin Baldridge, Jim Bale, Michael Bamshad, Deborah Barbouth, Pinar Bayrak‐Toydemir, Anita Beck, Alan H. Beggs, Edward Behrens, Gill Bejerano, Hugo J. Bellen, Jimmy Bennett, Beverly Berg‐Rood, Jonathan A. Bernstein, Gerard T. Berry, Anna Bican, Stephanie Bivona, Elizabeth Blue, John Bohnsack, Devon Bonner, Lorenzo Botto, Brenna Boyd, Lauren C. Briere, Gabrielle Brown, Elizabeth A. Burke, Lindsay C. Burrage, Manish J. Butte, Peter Byers, William E. Byrd, John Carey, Olveen Carrasquillo, Thomas Cassini, Ta Chen Peter Chang, Sirisak Chanprasert, Hsiao‐Tuan Chao, Gary D. Clark, Terra R. Coakley, Laurel A. Cobban, Joy D. Cogan, Matthew Coggins, F. Sessions Cole, Heather A. Colley, Heidi Cope, Rosario Corona, William J. Craigen, Andrew B. Crouse, Michael Cunningham, Precilla D'Souza, Hongzheng Dai, Surendra Dasari, Joie Davis, Jyoti G. Dayal, Esteban C. Dell'Angelica, Katrina Dipple, Daniel Doherty, Naghmeh Dorrani, Argenia L. Doss, Emilie D. Douine, Dawn Earl, David J. Eckstein, Lisa T. Emrick, Christine M. Eng, Marni Falk, Elizabeth L. Fieg, Paul G. Fisher, Brent L. Fogel, Irman Forghani, William A. Gahl, Ian Glass, Bernadette Gochuico, Page C. Goddard, Rena A. Godfrey, Katie Golden‐Grant, Alana Grajewski, Don Hadley, Sihoun Hahn, Meghan C. Halley, Rizwan Hamid, Kelly Hassey, Nichole Hayes, Frances High, Anne Hing, Fuki M. Hisama, Ingrid A. Holm, Jason Hom, Martha Horike‐Pyne, Alden Huang, Sarah Hutchison, Wendy Introne, Rosario Isasi, Kosuke Izumi, Fariha Jamal, Gail P. Jarvik, Jeffrey Jarvik, Suman Jayadev, Orpa Jean‐Marie, Vaidehi Jobanputra, Lefkothea Karaviti, Shamika Ketkar, Dana Kiley, Gonench Kilich, Shilpa N. Kobren, Isaac S. Kohane, Jennefer N. Kohler, Susan Korrick, Mary Kozuira, Deborah Krakow, Donna M. Krasnewich, Elijah Kravets, Seema R. Lalani, Byron Lam, Christina Lam, Brendan C. Lanpher, Ian R. Lanza, Kimberly LeBlanc, Brendan H. Lee, Roy Levitt, Richard A. Lewis, Pengfei Liu, Xue Zhong Liu, Nicola Longo, Sandra K. Loo, Joseph Loscalzo, Richard L. Maas, Ellen F. Macnamara, Calum A. MacRae, Valerie V. Maduro, AudreyStephannie Maghiro, Rachel Mahoney, May Christine V. Malicdan, Laura A. Mamounas, Teri A. Manolio, Rong Mao, Kenneth Maravilla, Ronit Marom, Gabor Marth, Beth A. Martin, Martin G. Martin, Julian A. Martínez‐Agosto, Shruti Marwaha, Jacob McCauley, Allyn McConkie‐Rosell, Alexa T. McCray, Elisabeth McGee, Heather Mefford, J. Lawrence Merritt, Matthew Might, Ghayda Mirzaa, Eva Morava, Paolo Moretti, John Mulvihill, Mariko Nakano‐Okuno, Stanley F. Nelson, John H. Newman, Sarah K. Nicholas, Deborah Nickerson, Shirley Nieves‐Rodriguez, Donna Novacic, Devin Oglesbee, James P. Orengo, Laura Pace, Stephen Pak, J. Carl Pallais, Christina G.S. Palmer, Jeanette C. Papp, Neil H. Parker, John A. Phillips, Jennifer E. Posey, Lorraine Potocki, Barbara N. Pusey Swerdzewski, Aaron Quinlan, Deepak A. Rao, Anna Raper, Wendy Raskind, Genecee Renteria, Chloe M. Reuter, Lynette Rives, Amy K. Robertson, Lance H. Rodan, Jill A. Rosenfeld, Natalie Rosenwasser, Francis Rossignol, Maura Ruzhnikov, Ralph Sacco, Jacinda B. Sampson, Mario Saporta, Judy Schaechter, Timothy Schedl, Kelly Schoch, Daryl A. Scott, C. Ron Scott, Vandana Shashi, Jimann Shin, Edwin K. Silverman, Janet S. Sinsheimer, Kathy Sisco, Edward C. Smith, Kevin S. Smith, Lilianna Solnica‐Krezel, Ben Solomon, Rebecca C. Spillmann, Joan M. Stoler, Kathleen Sullivan, Jennifer A. Sullivan, Angela Sun, Shirley Sutton, David A. Sweetser, Virginia Sybert, Holly K. Tabor, Queenie K.‐G. Tan, Amelia L. M. Tan, Mustafa Tekin, Fred Telischi, Willa Thorson, Cynthia J. Tifft, Camilo Toro, Alyssa A. Tran, Rachel A. Ungar, Tiina K. Urv, Adeline Vanderver, Matt Velinder, Dave Viskochil, Tiphanie P. Vogel, Colleen E. Wahl, Melissa Walker, Stephanie Wallace, Nicole M. Walley, Jennifer Wambach, Jijun Wan, Lee‐kai Wang, Michael F. Wangler, Patricia A. Ward, Daniel Wegner, Monika W. Hubshman, Mark Wener, Tara Wenger, Monte Westerfield, Matthew T. Wheeler, Jordan Whitlock, Lynne A. Wolfe, Kim Worley, Changrui Xiao, Shinya Yamamoto, John Yang, Zhe Zhang, Stephan Zuchner, Michael J. Bamshad, Fuki M. Hisama, Gail P. Jarvik, Katrina M. Dipple, Matthias A. Hediger, Andrew B. Stergachis +329 morewiley +1 more sourceEvaluation of phytoconstituents of Triticum aestivum grass extracts on nutritional attributes, antioxidant, and antimicrobial activities against food pathogens with molecular in silico investigation
Food Frontiers, Volume 4, Issue 2, Page 831-848, June 2023., 2023 The present study elaborates on the nutritional, antioxidant and antimicrobial potential of a non‐genetically modified type of T. aestivum grass, along with the evidence of molecular docking studies. The compound extracted from T. aestivum was docked against the antioxidant protein and antimicrobial drug targets.Mohandass Kaviya, Balasubramanian Balamuralikrishnan, Thangavelu Sangeetha, Natchiappan Senthilkumar, Arunkumar Malaisamy, Murugasamy Sivasamy, Loganathan Poorni, Karthika Pushparaj, Meyyazhagan Arun, Arumugam Vijaya Anand +9 morewiley +1 more sourceChatGPT: Cross-cultural tourism research imperative
Journal of Economics and Management, 2023 Aim/purpose – Cultural differences play an influential role in driving tourism development and varying outcomes of technology acceptance. The impact of ChatGPT on tourism is yet to be explored.Chen Sirong, Zhang Ke, Li Xiaonan, Ye Huiyue, Lin Katsy Jiaxin, Law Rob +5 moredoaj +1 more source
