Results 171 to 180 of about 20,426,999 (313)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

lncRNA LINC00460 promoted colorectal cancer cells metastasis via miR-939-5p sponging

Cancer Management and Research, 2019
Yueyan Zhang,1* Xingchi Liu,2* Qiang Li,1* Yong Zhang1 1Department of Pathology, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Shenyang, People’s Republic of China; 2Department of Thoracic Surgery, General ...
Zhang Y, Liu XC, Li Q, Zhang Y
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Letter with attachment: Almere L. Scott to Ida M. Tarbell, July 15, 1931

, 1931
Letter with copy of letter, Almere L.
Scott, Almere L.
core  

A selective and augmentable butyrate-FFAR2 signal circuitry programs the cellular identity of enteroendocrine L-cells. [PDF]

Commun Biol
Hirdaramani A, Cheng CW, Hanyaloglu AC, Frost G.   +3 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Immunometabolite L-2-HG promotes epigenetic modification of exhausted T cells and improves antitumor immunity

JCI Insight
This study aimed to explore the potential correlation between the metabolic intermediate L-2-hydroxyglutarate (L-2-HG) and T cell exhaustion, as well as the underlying mechanisms involved.
Yanying Yang, Xiaoyan Li, Fangming Liu, Mingyue Ma, Ying Yang, Chengchao Ruan, Yan Lu, Xiaoyang Li, Xiangdong Wang, Yinghong Shi, Zheng Zhang, Hua Wang, Zhouli Cheng, Duojiao Wu   +13 more
doaj   +1 more source

Glucocorticoid-induced Leucine Zipper (GILZ) is a novel secreted protein by intestinal L-cells and is dysregulated during active ulcerative colitis. [PDF]

Cell Death Discov
Rosati L, Leoncini G, Cari L, Sette MR, Procaccini M, Nocentini G, Villanacci V, Riccardi C, Migliorati G, Ronchetti S.   +9 more
europepmc   +1 more source

Glucagon-Like Peptide-1 Secreting L-Cells Coupled to Sensory Nerves Translate Microbial Signals to the Host Rat Nervous System. [PDF]

Front Cell Neurosci, 2020
Buckley MM, O'Brien R, Brosnan E, Ross RP, Stanton C, Buckley JM, O'Malley D.   +6 more
europepmc   +1 more source