Results 141 to 150 of about 9,724 (224)

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Differential microRNAs and metabolites in the breast milk of mothers with adverse childhood experiences. [PDF]

Transl Psychiatry
Tomaszewska W, Apanasewicz A, Gomółka M, Matyas M, Rojek P, Szołtysik M, Babiszewska-Aksamit M, Gielniewski B, Wojtas B, Ziomkiewicz A, Jawaid A.   +10 more
europepmc   +1 more source

CARE‐ing for concussions: Development of the Calgary Adapted aRm Ergometer (CARE) exertion test: A physiological alternative to the Calgary Concussion Cycle Test

Experimental Physiology, EarlyView.
Abstract Aerobic exercise testing helps facilitate recovery post‐concussion. Current protocols (Calgary Concussion Cycling Test: CCCT) are inaccessible for athletes with lower‐body impairments (i.e. Para athletes). This study compared physiological parameters for a novel arm crank test, the Calgary Adapted aRm Ergometer (CARE) test, with the CCCT ...
Jonathan D. Smirl, Joshua J. Burkart, Matthew G. Neill, Jean‐Michel Galarneau, Elizabeth K. S. Fletcher, Joel S. Burma, Nathan E. Johnson, John J. Leddy, Mohammad N. Haider, William M. Adams, Cheri Blauwet, Chantel T. Debert, Carolyn A. Emery   +12 more
wiley   +1 more source

Functional polymorphisms in pigmentation-related genes <i>MC1R</i> and <i>DCT</i> display population-specific association with wet age-related macular degeneration. [PDF]

Biochem Biophys Rep
Reinisalo M, Helisalmi S, Koskela A, Küblbeck J, Liukkonen M, Mutikainen M, Cree AJ, Griffiths H, Papp A, Seitsonen S, Immonen I, Soininen H, Urtti A, Hiltunen M, Winiarczyk M, Resch M, Ratnayaka JA, Lotery AJ, Kaarniranta K, Honkakoski P.   +19 more
europepmc   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Decentralized Clinical Trials in the Era of Real-World Evidence: A Critical Assessment of Recent Experiences. [PDF]

Clin Transl Sci
Wang H, Daizadeh N, Shen YL, Chen J, Rockhold FW, Pang H, Lee H.   +6 more
europepmc   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Agreement of treatment effects in decentralised trials versus traditional trials: meta-epidemiological study.

BMJ
Chaboud L, Janiaud P, Hirt J, Hemkens LG.   +3 more
europepmc   +1 more source

Processing of ENaC in mouse kidney: effects of aldosterone and a Liddle syndrome mutation. [PDF]

Am J Physiol Renal Physiol
Frindt G, Yang L, Rohan T, Palmer LG.
europepmc   +1 more source

APOE4 negates the effects of ovarian hormones on cerebrovascular endothelial and mitochondrial function

The Journal of Physiology, EarlyView.
Abstract figure legend We examined the interaction effect of ovarian hormones and APOE genotype on cerebrovascular and mitochondrial function. Our data revealed that APOEε3 mice that were ovariectomized exhibited impaired endothelial function and greater oxidative stress and inflammation compared to sham controls.
Mackenzie N. Kehmeier, Alexandra Famiano, Abigail E. Cullen, Thomas Leonhardt, Skylyn J. Ferguson, Madeleine Snyder, Carrie E. McCurdy, Daniel J. Tyrrell, Nabil J. Alkayed, Ashley E. Walker   +9 more
wiley   +1 more source