Results 151 to 160 of about 9,724 (224)

Operationalizing Decentralized Clinical Trials: Technology Insights from the Trials@Home RADIAL Proof-of-Concept Trial. [PDF]

Clin Pharmacol Ther
Hanke S, Giannikopoulos D, Neumayer B, Vedenkannas T, Davey R, Mpaltadoros L, Guthrie B, Jackson R, Lagerwaard B, Zuidgeest M, Trials@Home consortium.   +10 more
europepmc   +1 more source

Real‐World Outcomes of FLAG‐Ida Regimen in 1079 Adult Patients With First Relapsed/Refractory AML: A PETHEMA Study

American Journal of Hematology, Volume 101, Issue 7, Page 1692-1705, July 2026.
ABSTRACT In a large multicenter real‐world cohort, we aimed to evaluate outcomes of FLAG‐Ida salvage therapy for relapsed/refractory (R/R) acute myeloid leukemia (AML) and validated the SALFLAGE prognostic score. We analyzed 1079 adults with R/R AML treated across 112 PETHEMA institutions over 26 years (1998–2024), including patients with primary ...
Gaspar Aspas Requena, Rebeca Rodríguez‐Veiga, Cristina Gil, Carmen Botella, Eliana Aguiar, Fernanda Trigo, Mercedes Colorado, Teresa del Bernal del Castillo, Eva Barragan, Mar Tormo, Eduardo Rodríguez Arbolí, Josefina Serrano López, Raimundo García Boyero, Tamara Castaño, Pilar Herrera Puente, Mónica A. Romero Riquelme, María J. Sayas Lloris, Lorenzo Algarra‐Algarra, Carlos Rodriguez‐Medina, Claudia L. Sossa Melo, Jorge Labrador Gomez, Susana Vives, Olga Salamero, María Luz Amigo, Marta Valero Nuñez, Christine Rojas, Francisca Bass, María García‐Fortes, Belén Vidriales Vicente, Marta Polo, Celina Benavente, María D. Madrigal, Marcela Espinoza, Manuel Pérez‐Encinas, María L. Amador Barciela, Guiomar Bautista, Antonio Solana‐Altabella, Isabel Cano‐Ferri, Rafael Colmenares, Patricia García‐Ramírez, Francisco Ibáñez Alis, Manuel Barrios García, Gabriela Rodríguez‐Macías, Miguel López, Ana Yurena Oliva Hernández, Carlos Javier Cerveró, David Martínez‐Cuadrón, Pedro Chorão, Juan M. Bergua Burgues, Pau Montesinos   +49 more
wiley   +1 more source

Advancing translational science through trial integrity: REDCap-based approaches to mitigating fraud and bias. [PDF]

J Clin Transl Sci
Fronk GE, Hawk LW, Cates A, Clark J, Natale N, Dahne J.   +5 more
europepmc   +1 more source

Oxidative Stress‐Induced Expression Levels of PXDN and NF‐κB in Type 2 Diabetic Patients With Nephropathy

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
PXDN expression is markedly upregulated in diabetic nephropathy and, versus NF‐κB and oxidative stress markers, shows superior diagnostic performance (AUC 0.79; 90% specificity), supporting PXDN as a sensitive, specific non‐invasive biomarker for early DN.
Zakira Hanin, Aisha Anees Ahmed, Shuhd Salem Al Nahdi, Sumayya Althaf Kasim, Mahir Khalil Jallo, Rajaram Rhambau Jagdale, Dalia A. Gaber   +6 more
wiley   +1 more source

KCC3 is not required for the distal convoluted tubule response to reduced dietary potassium intake. [PDF]

Am J Physiol Renal Physiol
Inoue MK, Yu A, Ferdaus MZ, Zhang Y, Su XT, Bock F, Arroyo JP, Cho KY, Ellison DH, Zhang MZ, Harris RC, Delpire E, Terker AS.   +12 more
europepmc   +1 more source

Co‐Designing and Evaluating a Digital Competencies Toolkit for Nursing Students

Journal of Advanced Nursing, Volume 82, Issue 7, Page 7541-7561, July 2026.
ABSTRACT Aim To offer a student‐focused critical evaluation of the content and use of a digital competencies discipline‐specific toolkit that was co‐designed with students, offering ideas for training and development across several digital skills areas, such as digital creation, research, communication, innovation, and wellbeing.
Konstantina Martzoukou, Errol Sadullah Luders, Moisés Piedade Henriques, Khairun Nisah Kamaruzaman   +3 more
wiley   +1 more source

The Supply of Investigational Medicinal Product and Management of Study Materials for Decentralized Participants-Insights from the Trials@Home RADIAL Proof-of-Concept Trial. [PDF]

Clin Pharmacol Ther
Heath M, de Jong AJ, Magorrian-Spence S, Jin C, van Weelij DR, Pagnier L, van Rijswick Y, Haufe V, Lagerwaard B, Zuidgeest MGP, Trials@Home consortium.   +10 more
europepmc   +1 more source

Effects of Elevated CO2 on Bean Pod Mottle Virus Infection in Both Incompatible and Compatible Interactions With Phaseolus vulgaris L

Plant, Cell &Environment, Volume 49, Issue 7, Page 4493-4512, July 2026.
ABSTRACT Plant viruses cause significant crop losses, a situation that could worsen due to anthropogenic activities driving global climate change, one factor of which is the increase in atmospheric CO2 concentration. This study assessed the impact of elevated CO2 concentration (eCO2, 1000 vs. 400 ppm) on two genotypes of common bean (Phaseolus vulgaris
Tiffanie Scandolera, Julie Lintz, Ariane Gratias, Ellea Aboud, Simon Rochoux, Maria V. Préjean, Gilles Chatel Innocenti, Marie Garmier, Gianluca Teano, Juan C. Alvarez‐Diaz, Graham Noctor, Valérie Geffroy, Stéphanie Pflieger   +12 more
wiley   +1 more source

Building HOPE: operationalizing hybrid decentralized oncology clinical trials with community providers beyond traditional healthcare system networks. [PDF]

Oncologist
Morrison JK, Kiefer LV, Camp A, Moore E, Laffan M, Adams B, Maccarone J, Kelly E, Knutsen M, Scott S, Robinson R, Huamani-Bundy J, Burns N, Haines M, Crecelius E, Sud S, Finch K, Potter J, Wheeler SB, Martin BA, Lee C.   +20 more
europepmc   +1 more source

Context‐Dependent Effects of Apolipoprotein A2 on Lipid Metabolism and Atherogenesis

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Proposed model of the pro‐atherogenic role of APOA2 in dyslipidemia. Under conditions of dyslipidemia (ldlr−/− and apoe−/− mice), APOA2 promotes a reduction in VLDL through its conversion to LDL via an LDLR‐independent pathway. LDL is then deposited to the aorta and aortic root. In the ldlr−/− mice, the presence of APOE may mitigate the rate of VLDL to
Evangelia Zvintzou, Ioana Madalina Fenyo, Radu Ionita, Georgia Kakafoni, Madalina Dumitrescu, Maria Alemi, Bianca Sanziana Daraban, Konstantinos Marinos, Anca Violeta Gafencu, Kyriakos E. Kypreos   +9 more
wiley   +1 more source