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Biosensors, 2023 Label-free biosensors have become an indispensable tool for analyzing intrinsic molecular properties, such as mass, and quantifying molecular interactions without interference from labels, which is critical for the screening of drugs, detecting disease ...
Pengfei Zhang, Rui Wang
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Label-free drug discovery [PDF]
Frontiers in Pharmacology, 2014 Current drug discovery is dominated by label-dependent molecular approaches, which screen drugs in the context of a predefined and target-based hypothesis in vitro.
Ye eFang
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Label-Free MicroRNA Optical Biosensors [PDF]
Nanomaterials, 2019 MicroRNAs (miRNAs) play crucial roles in regulating gene expression. Many studies show that miRNAs have been linked to almost all kinds of disease. In addition, miRNAs are well preserved in a variety of specimens, thereby making them ideal biomarkers for
Meimei Lai, Gymama Slaughter
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Label‐Free and Immobilization‐Free Protein‐Binding Assays by Ultraviolet Transient Absorption Microscopy [PDF]
Advanced ScienceProtein–ligand interactions are central to understanding biological mechanisms and drug discovery, yet conventional assays often rely on labeling or immobilization that can alter natural binding.
Jianghao Shen +5 more
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Label-Free Single-Molecule Conalbumin Analysis [PDF]
MicromachinesNanoaperture optical tweezers (NOTs) were used to analyze conalbumin in various forms. By analyzing the power spectrum of the NOT-transmitted laser signal, differences between iron and iron-free conalbumin were observed; the corner frequency extrapolated
Tianyu Zhao, Xi Ren, Reuven Gordon
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Label‐Free Single‐Molecule Immunoassay [PDF]
Advanced ScienceSingle‐molecule immunoassay is a reliable technique for the detection and quantification of low‐abundance blood biomarkers, which are essential for early disease diagnosis and biomedical research.
Xiaoyan Zhou +11 more
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Multimodal label-free microscopy [PDF]
Journal of Innovative Optical Health Sciences, 2014 This paper reviews the different multimodal applications based on a large extent of label-free imaging modalities, ranging from linear to nonlinear optics, while also including spectroscopic measurements.
Nicolas Pavillon +2 more
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Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes [PDF]
Advanced ScienceAstrocyte cell differentiation to their characteristic starlike morphology with the expression of proteins in microdomains, critical for normal brain function, occurs naturally in‐vivo but can be affected in pathological condition or in cell culture in ...
Panagis D. Samolis +9 more
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Label-Free Microdroplet Concentration Detector Based on a Quadruple Resonant Ring Metamaterial [PDF]
SensorsThis paper proposes and experimentally validates a label-free microdroplet concentration detector based on a quad-resonator metamaterial. The device exploits the linear relationship between the dielectric constant of a binary mixed solution and its ...
Wenjin Guo, Yinuo Cheng, Jian Li
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A review on label free biosensors
Biosensors and Bioelectronics: X, 2022 Label-free biosensing has advanced significantly in recent years due to its capacity for quick and inexpensive bio-detection in small volumes. Additionally, they have developed into lab-on-a-chip technology and may be able to perform real-time analysis ...
Vimala Rani Samuel, K.Jagajjanani Rao
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