Results 101 to 110 of about 6,064,561 (323)

Rare-cell enrichment by a rapid, label-free, ultrasonic isopycnic technique for medical diagnostics [PDF]

, 2014
One significant challenge in medical diagnostics lies in the development of label-free methods to separate different cells within complex biological samples.
Bell, Bourquin, Chappuis, Franke, Friend, Grover, Kumar, Leif, Lejon, Minion, Nash, Raghavan, Reboud, Rogers, Tan, Urdea, Wilson, Yager, Yatsushiro   +18 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Label‐Free Photonic Biosensors: Key Technologies for Precision Diagnostics

ChemistryEurope
With the rise of multidrug‐resistant pathogens, emerging zoonotic viruses, and the increasing prevalence of cancer, the modernization of clinical diagnostics has become a critical priority.
Maria Soler, Laura M. Lechuga
doaj   +1 more source

Label-free photoacoustic ophthalmic angiography [PDF]

, 2010
We present label-free functional photoacoustic imaging of the ocular microvasculature in living animals. The anterior segment of an adult mouse was imaged with a laser exposure level well within the American National Standards Institute safety standards.
Hu, Song, Maslov, Konstantin, Rao, Bin, Wang, Lihong V.   +3 more
core  

Chemically Functionalised Graphene FET Biosensor for the Label-free Sensing of Exosomes

Scientific Reports, 2019
A graphene field-effect transistor (gFET) was non-covalently functionalised with 1-pyrenebutyric acid N-hydroxysuccinimide ester and conjugated with anti-CD63 antibodies for the label-free detection of exosomes.
Deana Kwong Hong Tsang, Tyler J. Lieberthal, C. Watts, I. Dunlop, S. Ramadan, Armando E. del Río Hernández, N. Klein   +6 more
semanticscholar   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Cell segmentation methods for label-free contrast microscopy: review and comprehensive comparison

BMC Bioinformatics, 2019
Because of its non-destructive nature, label-free imaging is an important strategy for studying biological processes. However, routine microscopic techniques like phase contrast or DIC suffer from shadow-cast artifacts making automatic segmentation ...
Tomáš Vičar, J. Balvan, J. Jaros, Florian Jug, R. Kolář, M. Masařík, J. Gumulec   +6 more
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Label‐Free Microfluidic Apheresis of Circulating Tumor Cell Clusters

Advanced Science
Screening liters of blood (i.e., apheresis) represents a generalized approach to promote the reliable access to circulating tumor cell clusters (CTCCs), which are known to be highly metastasis‐competent, yet ultrarare.
Li Zhan, Jon Edd, Avanish Mishra, Mehmet Toner   +3 more
doaj   +1 more source

Combined Lab-on-a-Chip and microarray approach for biomolecular interaction sensing using surface plasmon resonance imaging [PDF]

, 2007
Surface plasmon resonance imaging (SPR) is a well-established label-free detection technique for real-time biomolecular interaction measurements.
Berg, A. van den, Beusink, J.B., Boer, H.L. de, Carlen, E.T., Krishnamoorthy, G., Schasfoort, R.B.M., Schlautmann, S.   +6 more
core   +1 more source