Results 111 to 120 of about 518,105 (292)

Biophotonic Sensing Cells (BICELLs) for label-free biosensing [PDF]

, 2013
Label free immunoassay sector is a ferment of activity, experiencing rapid growth as new technologies come forward and achieve acceptance. The landscape is changing in a “bottom up” approach, as individual companies promote individual technologies and ...
Barrios, C.A., Bañuls, María José, Canalejas Tejero, Victor, Casquel del Campo, Rafael, Holgado Bolaños, Miguel, Laguna Heras, Maria Fe, Lavin Hueros, Alvaro, López, A., Puchades, Rosa, Sanza Gutiérrez, Francisco Javier   +9 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Label-free 3D molecular imaging of living tissues using Raman spectral projection tomography

Nature Communications
The ability to image tissues in three dimensions (3D) with label-free molecular contrast at the mesoscale would be a valuable capability in biology and biomedicine.
Elzbieta Stepula, Anders R. Walther, Magnus Jensen, Dev R. Mehrotra, Mu H. Yuan, Simon V. Pedersen, Vishal Kumar, Eileen Gentleman, Michael B. Albro, Martin A. B. Hedegaard, Mads S. Bergholt   +10 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Au-Ag template stripped pattern for scanning probe investigations of DNA arrays produced by Dip Pen Nanolithography

, 2008
We report on DNA arrays produced by Dip Pen Nanolithography (DPN) on a novel Au-Ag micro patterned template stripped surface. DNA arrays have been investigated by atomic force microscopy (AFM) and scanning tunnelling microscopy (STM) showing that the ...
Alessandrini A., Blackstock J. J., Bustamante C., Davis J. J., Demers L. M., Demers L. M., DeRisi J., DeRisi J. L., Diebel J., Ginger D. S., Hartschuch A., Hegner M., Heller R. A., Hong S. H., Kim J. M., Lander E. S., Lee S., Legay G., Losic D., Lyubchenko Y. L., Patole S.N., Piner R. D., Rosi N. L., Rospigliosi A., Rozhok S., Salaita K., Salaita K., Schena M., Shapir E., Shapir E., Sinensky A. K., van Hal N. L. W., Vettiger P., Wagner P., Yu X., Zhou D. J., Zhou D. J.   +36 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

From superior contrast to super resolution label free optical microscopy

npj Imaging
Label-free optical microscopy utilizes the information encoded in light scattered off unlabeled particles to generate the images. This review article starts off with a discussion on how this light matter interaction gives rise to the issues of poor ...
Nikhil Jayakumar, Balpreet Singh Ahluwalia   +1 more
doaj   +1 more source

Route Towards a Label-free Optical Waveguide Sensing Platform Based on Lossy Mode Resonances [PDF]

, 2019
According to recent market studies of the North American company Allied Market Research, the field of photonic sensors is an emerging strategic field for the following years and it is expected to garner $18 billion by 2021.
Arregui, Francisco Javier, Ascorbe, Joaquin, Corres, Jesús María, De Acha, Nerea, Del Villar, Ignacio, Diaz, S., Elosúa, César, Goicoechea, Javier, Hernaez, Miguel, Imas, J. J., Lopez, D., Matias, Ignacio Raul, Ozcariz, A., Socorro, A.B., Urrutia, Aitor, Vitoria, I., Zamarreño, Carlos R., Zubiate, Pablo   +17 more
core