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Label-free biosensors have become an indispensable tool for analyzing intrinsic molecular properties, such as mass, and quantifying molecular interactions without interference from labels, which is critical for the screening of drugs, detecting disease ...
Pengfei Zhang, Rui Wang
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Label-free drug discovery [PDF]
Current drug discovery is dominated by label-dependent molecular approaches, which screen drugs in the context of a predefined and target-based hypothesis in vitro.
Ye eFang
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A review on label free biosensors
Label-free biosensing has advanced significantly in recent years due to its capacity for quick and inexpensive bio-detection in small volumes. Additionally, they have developed into lab-on-a-chip technology and may be able to perform real-time analysis ...
Vimala Rani Samuel, K.Jagajjanani Rao
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Label-Free MicroRNA Optical Biosensors
MicroRNAs (miRNAs) play crucial roles in regulating gene expression. Many studies show that miRNAs have been linked to almost all kinds of disease. In addition, miRNAs are well preserved in a variety of specimens, thereby making them ideal biomarkers for
Meimei Lai, Gymama Slaughter
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Label-free microfluidic sorting of microparticles
Massive growth of the microfluidics field has triggered numerous advances in focusing, separating, ordering, concentrating, and mixing of microparticles.
Jian Zhou +4 more
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Label‐Free Single‐Molecule Immunoassay
Single‐molecule immunoassay is a reliable technique for the detection and quantification of low‐abundance blood biomarkers, which are essential for early disease diagnosis and biomedical research.
Xiaoyan Zhou +11 more
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Label-Free Single-Molecule Conalbumin Analysis [PDF]
Nanoaperture optical tweezers (NOTs) were used to analyze conalbumin in various forms. By analyzing the power spectrum of the NOT-transmitted laser signal, differences between iron and iron-free conalbumin were observed; the corner frequency extrapolated
Tianyu Zhao, Xi Ren, Reuven Gordon
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Zero‐shot temporal event localisation: Label‐free, training‐free, domain‐free
Temporal event localisation (TEL) has recently attracted increasing attention due to the rapid development of video platforms. Existing methods are based on either fully/weakly supervised or unsupervised learning, and thus they rely on expensive data ...
Li Sun +4 more
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Label-free photoacoustic nanoscopy [PDF]
Super-resolution microscopy techniques - capable of overcoming the diffraction limit of light - have opened new opportunities to explore subcellular structures and dynamics not resolvable in conventional far-field microscopy. However, relying on staining with exogenous fluorescent markers, these techniques can sometimes introduce undesired artifacts to
Danielli, Amos +8 more
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Multimodal label-free microscopy [PDF]
This paper reviews the different multimodal applications based on a large extent of label-free imaging modalities, ranging from linear to nonlinear optics, while also including spectroscopic measurements.
Nicolas Pavillon +2 more
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