Results 51 to 60 of about 3,139,625 (302)

Label-free haemogram using wavelength modulated Raman spectroscopy for identifying immune-cell subset

open access: yes, 2014
The authors thank the UK EPSRC the CR-UK/EPSRC/MRC/DoH (England) imaging Program and the European Union project FAMOS (FP7 ICT, contract no. 317744) for funding, K.D. is a Royal Society-Wolfson Merit Award Holder.Leucocytes in the blood of mammals form a
Bavishna B. Praveen   +9 more
core   +1 more source

High‐Throughput, Label‐Free and Slide‐Free Histological Imaging by Computational Microscopy and Unsupervised Learning

open access: yesAdvanced Science, 2022
Rapid and high‐resolution histological imaging with minimal tissue preparation has long been a challenging and yet captivating medical pursuit. Here, the authors propose a promising and transformative histological imaging method, termed computational ...
Yan Zhang   +7 more
doaj   +1 more source

Label-Free Assays on the BIND System [PDF]

open access: yesSLAS Discovery, 2004
Screening of biochemical interactions becomes simpler, less expensive, and more accurate when labels, such as fluorescent dyes, radioactive markers, and colorimetric reactions, are not required to quantify detected material. SRU Biosystems has developed a biosensor technology that is manufactured on continuous sheets of plastic film and incorporated ...
Brian T, Cunningham   +9 more
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Label-free volumetric histopathology of thick-tissue slides - neuroendorine tumor

open access: yes, 2020
Label-free volumetric histopathology of thick-tissue slides - neuroendorine ...
yongkeun park (8695308)
core   +1 more source

A Label Free Electrochemical Nanobiosensor Study [PDF]

open access: yesAnalytical Letters, 2009
Abstract Nano-porous silicon (PS) is an attractive material for incorporation into biosensors, because it has a large surface area combined with the ability to generate both optical and electrical signals. In this paper, we describe a label-free nanobiosensor for bovine serum albumin (BSA).
Zhang, Juankun   +9 more
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Label-free volumetric histopathology of thick-tissue slides - cirrhotic nodule

open access: yes, 2020
Label-free volumetric histopathology of thick-tissue slides - intraductal papillary ...
yongkeun park (8695308)
core   +1 more source

Label-free quantification

open access: yes, 2023
Label-free quantification is an important mass spectrometry method that requires no specific sample labelingInstead, it utilized MS/MS generated signals of specific peptides for comparison to define protein expression modifications between samples. Two alternative label-free quantification strategies are frequently used.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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