Results 91 to 100 of about 58,664 (301)

Optical Label Switching Functionalities Employing Semiconductor Optical Amplifiers [PDF]

open access: yes, 2006
Optical labelling of data packets enables high router throughputs. Semiconductor optical amplifiers (SOAs) are key building blocks to implement the functionalities required for fast optical label ...
Vegas Olmos, J.J.   +23 more
core   +2 more sources

Adjunctive Use of Calcipotriene/Betamethasone Dipropionate Foam in a Real-World Setting Curtails the Cost of Biologics Without Reducing Efficacy in Psoriasis

open access: yesDermatology and Therapy, 2020
Introduction Although the efficacy of monotherapy with biologics for psoriasis is well established, many patients fail to achieve complete plaque clearance from their initial biologic treatment alone.
Jerry Bagel   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Dealing With Label Switching in Mixture Models

open access: yesJournal of the Royal Statistical Society Series B: Statistical Methodology, 2000
Summary In a Bayesian analysis of finite mixture models, parameter estimation and clustering are sometimes less straightforward than might be expected. In particular, the common practice of estimating parameters by their posterior mean, and summarizing joint posterior distributions by marginal distributions, often leads to nonsensical ...
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

HEALTH KNOWLEDGE AND CONSUMER USE OF NUTRITIONAL LABELS: THE ISSUE REVISITED [PDF]

open access: yes
The role of health knowledge in consumer use of nutritional labels on food packages is explored using data from the 1995 Diet and Health Knowledge Survey.
Capps, Oral, Jr.   +2 more
core   +1 more source

SCM optical label switching scheme in a WDM packet transmitter employing a switching SG-DBR laser [PDF]

open access: yes, 2006
We demonstrate an SCM optical label switching scheme with spectral efficiency of 0.4bit/s/Hz and a spectral density figure of merit of 1. We then employ this scheme in a WDM transmitter subsystem and we investigate the detrimental effects that switching ...
Smyth, Frank   +13 more
core   +1 more source

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