Results 81 to 90 of about 58,664 (301)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Optimasi Jaringan Routing Open Shortest Path First Dengan Menggunakan Multiprotocol Label Switching [PDF]

open access: yes, 2020
Routing adalah sebuah proses dimana item dapat disampaikan melalui sebuah rute jaringan yang terkonfigurasi untuk mencapai titik tujuan dari suatu lokasi.
Marcus, Ronald David   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

THE EFFECT OF FOOD LABEL USE ON NUTRIENT INTAKES: AN ENDOGENOUS SWITCHING REGRESSION ANALYSIS [PDF]

open access: yes
This study examines the impact of consumers'Â’ use of food labels on selected nutrient intakes of Americans. Endogenous switching regression techniques are employed to control for heterogeneity in the label use decision.
Capps, Oral, Jr.   +2 more
core   +1 more source

Label switching using the IPv6 address hierarchy [PDF]

open access: yes, 2000
Current label switching protocols can use routing, address, and address hierarchy information to group flows for cut-throughs that bypass IP forwarding. This paper examines a label switching solution that uses the IP version 6 (IPv6) address structure to
P Boustead (20184891)   +1 more
core  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Packet Forwarding With Multiprotocol Label Switching

open access: yes, 2007
MultiProtocol Label Switching (MPLS) is an emerging technology that aims to address many of the existing issues associated with packet forwarding in today-s Internetworking environment. It provides a method of forwarding packets at a high rate of speed by combining the speed and performance of Layer 2 with the scalability and IP intelligence of Layer 3.
R. N. Pise, S. A. Kulkarni, R. V. Pawar
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Providing quality of service to internet applications using multiprotocol label switching [PDF]

open access: yes, 2006
The growth of the Internet and the range of applications it now supports has created a need for improved traffic engineering techniques. One protocol which shows promise in this regard is Multiprotocol Label Switching (MPLS).
Dragos, Radu-Calin
core  

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