Results 81 to 90 of about 883,522 (286)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Generalized Labels for Lambda-Switch-Capable (LSC) Label Switching Routers. [PDF]
RFC, 2011 Tomohiro Otani, Dan Li
openaire +2 more sources
Study of FEC at edge node of optical code label switching network
Tongxin xuebao, 2012 The structure block of the optical code label switching network was built,and the design scheme for the forwarding equivalent classes (FEC)was proposed employing OCDM technology which was appropriate for variable packets transmission and allow the label ...
Yu-bao WANG, Shao-yu ZHI
doaj +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Bayesian mixture labeling and clustering [PDF]
, 2012 Label switching is one of the fundamental issues for Bayesian mixture modeling. It occurs due to the nonidentifiability of the components under symmetric priors. Without solving the label switching, the ergodic averages of component specific quantities
Yao, Weixin
core +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Traffic characteristics analysis in optical burst switching networks with optical label processing
Semina: Ciências Exatas e Tecnológicas, 2007 An analysis is carried out with burst-switching optical networks which use label processing consisting of orthogonal optical codes (OOC), considering traffic characteristics such as length/duration and arrival rate of bursts.
Edson Moschim +3 more
doaj
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Alleviating label switching with optimal transport
, 2021 © 2019 Neural information processing systems foundation. All rights reserved. Label switching is a phenomenon arising in mixture model posterior inference that prevents one from meaningfully assessing posterior statistics using standard Monte Carlo ...
Monteiller, Pierre +5 more
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source