Results 41 to 50 of about 261,108 (323)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Switching to riociguat: a potential treatment strategy for the management of CTEPH and PAH

Pulmonary Circulation, 2020
Currently, five classes of drug are approved for the treatment of pulmonary arterial hypertension (PAH): phosphodiesterase 5 inhibitors (PDE5i); endothelin receptor antagonists; prostacyclin analogs; the IP receptor agonist selexipag; and the soluble ...
Raymond L. Benza, Paul A. Corris, Hossein-Ardeschir Ghofrani, Manreet Kanwar, Vallerie V. McLaughlin, Amresh Raina, Gérald Simonneau   +6 more
doaj   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Simulasi Multi Protocol Label Switching Virtual Private Network (MPLS VPN) Dengan Virtual Local Area Network (VLAN) Menggunakan Router MIKROTIK [PDF]

, 2018
Untuk mendapatkan komunikasi yang cepat, aman, dan mudah diakses digunakan jaringan MPLS VPN menggunakan VLAN. Jaringan MPLS akan mengirimkan paket sesuai dengan label yang ada pada header paket ke tujuan yang diinginkan dan VPN akan membatasi siapa ...
Euginia, B. (Bertha), Ghozali, T. (Theresia)   +1 more
core  

Safety of long-term denosumab therapy: results from the open label extension phase of two phase 3 studies in patients with metastatic breast and prostate cancer [PDF]

, 2015
Purpose: Zoledronic acid (ZA) or denosumab treatment reduces skeletal-related events; however, the safety of prolonged therapy has not been adequately studied.
A Lipton, Ada Braun, Alexander Paterson, Alison T. Stopeck, AM Brufsky, AO Hoff, AT Stopeck, CR Dunstan, D Amadori, Denise Yardley, F Saad, F Saad, Frank Kueppers, GA Block, Huei Wang, Ingo Diel, Janet E. Brown, Jean-Jacques Body, JJ Body, Jorge Arellano, K Fizazi, K Fizazi, Karim Fizazi, Katia Tonkin, L Gedmintas, Lawrence Karsh, LS Rosen, MG Kris, Michael Carducci, Miguel Martín, MR Smith, MR Smith, Neal Shore, NS Tchekmedyian, Paul Sieber, R Paparodis, RE Coleman, RG Russell, S Doshi, SL Ruggiero, ST Chang, Tapan Maniar, XGEVA® (denosumab) US Package Insert, Yasuhiro Fujiwara   +43 more
core   +1 more source

Switching of Photocatalytic Tyrosine/Histidine Labeling and Application to Photocatalytic Proximity Labeling

International Journal of Molecular Sciences, 2022
Weak and transient protein interactions are involved in dynamic biological responses and are an important research subject; however, methods to elucidate such interactions are lacking. Proximity labeling is a promising technique for labeling transient ligand–binding proteins and protein–protein interaction partners of analytes via an irreversible ...
Keita Nakane, Haruto Nagasawa, Chizu Fujimura, Eri Koyanagi, Shusuke Tomoshige, Minoru Ishikawa, Shinichi Sato   +6 more
openaire   +2 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

All-Optical Packet Switching and Label Rewriting for Data Packets Beyond 160 Gb/s

IEEE Photonics Journal, 2010
In this paper, two different paradigms to realize a scalable all-optical packet switch with label swapping will be reviewed. The two paradigms are based on wavelength routing switch and space routing switch.
Nicola Calabretta, Hyun-Do Jung, Eduward Tangdiongga, Harmen Dorren   +3 more
doaj   +1 more source

Tunable 4-channel ultra-dense WDM demultiplexer with III-V photodiodes integrated in silicon-on-insulator [PDF]

, 2012
A tunable 4-channel ultra-dense WDM demultiplexer with 0.25nm channel spacing is demonstrated with III-V photodiodes integrated on Silicon-on-Insulator using rib waveguides.
De Heyn, Peter, Keyvaninia, Shahram, Trita, Andrea, Van Thourhout, Dries, Verstuyft, Steven   +4 more
core