Results 61 to 70 of about 759,283 (267)

The Social Marginalization of People Living with a Mentally Ill Label–Family, Friends, and Work

open access: yesQualitative Sociology Review, 2021
This paper is based on qualitative research among people diagnosed with a mental illness who voluntarily attend a mental health center. Such individuals are given a degrading “mentally ill” label, which transforms them into a “new” person.
Kateřina Maloušková, Martin Fafejta
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Biocompatible sulfonium-based covalent probes for endogenous tubulin fluorescence nanoscopy in live and fixed cells

open access: yesNature Communications
Fluorescent probes enable precise visualization of dynamic cellular processes, especially when combined with super-resolution imaging techniques that overcome the diffraction limit.
Marie Auvray   +4 more
doaj   +1 more source

Site-Specific Labeling of Protein Kinase CK2: Combining Surface Display and Click Chemistry for Drug Discovery Applications

open access: yesPharmaceuticals, 2016
Human CK2 is a heterotetrameric constitutively active serine/threonine protein kinase and is an emerging target in current anti-cancer drug discovery. The kinase is composed of two catalytic CK2α subunits and two regulatory CK2β subunits.
Christian Nienberg   +5 more
doaj   +1 more source

Between Condemnation and Restoration. The Idea and Practices of Restorative Justice in the Context of the Rehabilitation of Offenders

open access: yesJournal of Modern Science, 2022
Objectives The aim of this paper is to outline the specifics and meaning of the idea of restorative justice in the context of dealing with offenders, as well as the approach to crime, including its genesis, forms, and methods. Another important aspect is
Dawid Kamil Wieczorek
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Legal aspects of development of organic agriculture in Ukraine in the context of European integration [PDF]

open access: yesEkonomika Poljoprivrede (1979), 2020
In modern economic conditions, organic production is gaining global significance, partly addressing food security and contributing to the well-being of the population. Ukraine is in the top-20 of world leaders in the organic movement. In this regard, the
Ignatenko Iryna
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Magnetoencephalography Atlas Viewer for Dipole Localization and Viewing

open access: yesJournal of Imaging
Magnetoencephalography (MEG) is a noninvasive neuroimaging technique widely recognized for epilepsy and tumor mapping. MEG clinical reporting requires a multidisciplinary team, including expert input regarding each dipole’s anatomic localization.
N.C.d. Fonseca   +9 more
doaj   +1 more source

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