Results 151 to 160 of about 169,055 (257)

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro   +5 more
wiley   +1 more source

CONTRIBUTOS PARA UMA RENOVAÇÃO [PDF]

open access: yes, 2011
1. O Mestrado Integrado de Engenharia Civil da FEUP2. Novos Paradigmas da Engenharia Civil3. Preparação de Quadros Internacionais4. Captação de Estudantes para o 2º Ciclo5. Captação de Estudantes Estrangeiros6. Laboratórios, Aulas Laboratoriais e Visitas
Fernando Veloso Gomes
core  

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos   +4 more
wiley   +1 more source

Formulation‐Dependent Cytotoxic Effects of Commercial and Analytical‐Grade Mancozeb in C6 Glial Cells

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Mancozeb (MZ) is a widely used dithiocarbamate fungicide composed of manganese (Mn) and zinc (Zn) complexes. Increasing concern has been raised regarding its occupational and human health relevance, particularly due to its neurotoxic potential associated with Mn‐related cellular dysfunction.
Lavínia Lazzarotti   +5 more
wiley   +1 more source

Morpho‐Anatomical and HPTLC Investigations of Lysimachia nummularia L. (Primulaceae) Grown in Switzerland

open access: yesMicroscopy Research and Technique, EarlyView.
This research provides a complete morphoanatomical description of Lysimachia nummularia, as well as a HPTLC profile. Standard techniques of light and scanning electron microscopies, as well as standard techniques of HPTLC, were used. ABSTRACT Primulaceae are distributed all over the world, encompassing around 2590 species.
Carolina Sabedotti   +9 more
wiley   +1 more source

ESTUDO DE ALELOS MUTADOS EM GENE QUE PARTICIPA DA PRODUÇÃO E SECREÇÃO DE LIPOPROTEÍNAS EM PORTADORES CRÔNICOS DO VÍRUS DA HEPATITE C

open access: yesBrazilian Journal of Infectious Diseases, 2021
Thamiris Vaz Gago Prata   +5 more
doaj   +1 more source

Non‐Stationary Dry‐Spell Hazard Probabilities for Spain

open access: yesInternational Journal of Climatology, EarlyView.
This study assesses long‐term changes in dry‐spell hazard probabilities across Spain (1961–2024) using a novel non‐stationary extreme value framework applied to daily precipitation records from a dense observational network. Results show that dry‐spell duration and associated return levels are dominantly stationary, with non‐stationary models providing
S. M. Vicente‐Serrano   +13 more
wiley   +1 more source

Characterisation of Drought and Wet Events in the Paraíba do Sul River Basin—Brazil

open access: yesInternational Journal of Climatology, EarlyView.
Trend analysis identified statistically significant reductions in precipitation (at the 5% significance level) at specific pluviometric stations in São Paulo and Rio de Janeiro, while other areas, mainly in Minas Gerais, experienced significant increases in annual and seasonal rainfall, particularly during summer and spring. These significant trends at
Gildo Rafael de Almeida Santana   +4 more
wiley   +1 more source

Effects of testosterone and high‐dose anabolic steroids on orthodontic‐induced bone remodeling and root resorption: An animal study

open access: yesJournal of Periodontology, EarlyView.
Abstract Background This study investigates the impact of disruptions in testosterone levels on bone remodeling, root resorption, and periodontal ligament (PDL) during orthodontic tooth movement (OTM) in a pubertal male rat model. Methods Testosterone deficiency was induced through orchiectomy, and the anabolic‐androgenic steroid (AAS, testosterone ...
Caio Luiz Bitencourt Reis   +11 more
wiley   +1 more source

Optimizing germination and cultivation of edible halophytes using effluents from an IMTA system

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Halophytes offer nature‐based solutions to food insecurity and soil degradation, while their integration into integrated multi‐trophic aquaculture (IMTA) systems promotes circular economy practices. This study aimed to optimize the germination and cultivation of edible halophytic species, namely Limbarda crithmoides, Suaeda vera and
Viana Castañeda‐Loaiza   +5 more
wiley   +1 more source

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